The relationship between uric acid levels and graft function in renal transplant patients who discontinued steroid therapy.

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dc.contributor.authorColak, H.
dc.contributor.authorErsan, S.
dc.contributor.authorTanrisev, M.
dc.contributor.authorYilmaz, B.
dc.contributor.authorUral, O.
dc.contributor.authorUnal, Z.
dc.contributor.authorSert, I
dc.date.accessioned2024-08-25T18:35:59Z
dc.date.available2024-08-25T18:35:59Z
dc.date.issued2023
dc.departmentEge Üniversitesien_US
dc.description.abstractIntroduction: High uric acid levels are commonly encountered in kidney transplant recipients, and can be associated with allograft dysfunction. Our study aims to examine the relationship between UA levels and graft function in patients discontinuing steroids.Methods: In this single-center-retrospective study, 56 patients discontinued steroid therapy from among 678 RT patients transplanted from living donors between 1999-2020 were included. The mean age of the study group was 45.8 +/- 8.8 years. Causes of steroid discontinuation, creatinine levels concurrent with uric acid levels before and after steroid discontinuation (mean 3.9 +/- 2.1 years), acute rejection numbers, demographics, durations of dialysis and transplantation, medications, laboratory data, human leukocyte antigen (HLA) mismatch numbers, blood-pressure (BP), body mass index, delayed acute rejection (DAR) numbers (3 months post-transplantation) were all recorded.Results: Creatinine and uric acid levels were seen to have increased after steroid discontinuation, there was a significant relationship between them (p<0.001). Statistically significant correlation was found between increased creatinine levels after steroid discontinuation and graft survival with higher HLA mismatch; 39 (69.6%) patients with mismatch >= 2, and 17 patients with mismatch <2 (30.4%) (p=0.049) . No significant relationship was found between DAR numbers before and after steroid discontinuation, and creatinine levels after steroid discontinuation.Conclusion: Per model obtained as a result of multivariate linear analysis, hyperuricemia and HLA mismatch numbers (p= 0.048 and p= 0.044, respectively) are independent predictive factors for graft dysfunction in patients discontinuing steroids. Accordingly, negative effects of modeling should be kept in mind for long-term graft survival in patients who plan to continue with steroid-sparing regimens.en_US
dc.identifier.endpage23en_US
dc.identifier.issn0326-3428
dc.identifier.issn2346-8548
dc.identifier.issue1en_US
dc.identifier.scopus2-s2.0-85150832367en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage17en_US
dc.identifier.urihttps://hdl.handle.net/11454/100489
dc.identifier.volume43en_US
dc.identifier.wosWOS:000959446000003en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherAsoc Regional Dialisis Trasplantes Renalesen_US
dc.relation.ispartofRevista De Nefrologia Dialisis Y Trasplanteen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmz20240825_Gen_US
dc.subjectrenal transplanten_US
dc.subjecturic aciden_US
dc.subjectgraft functionen_US
dc.subjectdelayed acute rejectionen_US
dc.subjecthuman leukocyte antigenen_US
dc.subjectPathogenetic Roleen_US
dc.subjectAcute Rejectionen_US
dc.subjectHyperuricemiaen_US
dc.subjectHypertensionen_US
dc.subjectDysfunctionen_US
dc.subjectRisken_US
dc.subjectSurvivalen_US
dc.subjectOutcomesen_US
dc.subjectDiseaseen_US
dc.titleThe relationship between uric acid levels and graft function in renal transplant patients who discontinued steroid therapy.en_US
dc.typeArticleen_US

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