neo-Clerodanes from Teucrium divaricatum subsp. divaricatum and their biological activity assessment

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dc.authorscopusid57211789902
dc.authorscopusid57202041549
dc.authorscopusid6507359466
dc.authorscopusid35558727300
dc.authorscopusid57988074900
dc.authorscopusid7003998497
dc.contributor.authorAydogan, Fadime
dc.contributor.authorAli, Zulfiqar
dc.contributor.authorZulfiqar, Fazila
dc.contributor.authorKaraalp, Canan
dc.contributor.authorKhan, Ikhlas A.
dc.contributor.authorBedir, Erdal
dc.date.accessioned2024-08-25T18:47:56Z
dc.date.available2024-08-25T18:47:56Z
dc.date.issued2023
dc.departmentEge Üniversitesien_US
dc.description.abstractFifteen neo-clerodane diterpenoids (1-15), including two undescribed glycosides, teudivaricosides A (1) and B (2), together with a known iridoid glycoside (16) and a phenylpropanoid glycoside (17) from the whole plant of Teucrium divaricatum subsp. divaricatum were isolated. Their structures were determined by spectral data analysis including 1D and 2D NMR and HRESIMS. Neo-clerodane diterpenoids were evaluated for their anti-inflammatory, and antimicrobial activities. None of them showed significant antimicrobial activity against various bacterial and fungal strains (up to 20 mu g/mL). All tested compounds were inactive up to the highest tested concentration of 50 mu M on iNOS inhibitory activity.en_US
dc.description.sponsorshipEge University Scientific Research Project [18-ECZ-013]; United States Department of Agriculture, Agricultural Research Service [58-6060-6-015]en_US
dc.description.sponsorshipThis project was supported by Ege University Scientific Research Project-18-ECZ-013. The requisite resources for this research were provided by Discovery & Development of Natural Products for Pharmaceutical & Agrichemical Applications, funded by the United States Department of Agriculture, Agricultural Research Service, Specific Cooperative Agreement No. 58-6060-6-015. The authors thank Dr. Shabana I. Khan, Dr. Siddharth K. Tripathi, and their co-workers for performing the biological assays.en_US
dc.identifier.doi10.1016/j.phytol.2023.01.010
dc.identifier.endpage49en_US
dc.identifier.issn1874-3900
dc.identifier.issn1876-7486
dc.identifier.scopus2-s2.0-85146858756en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage45en_US
dc.identifier.urihttps://doi.org/10.1016/j.phytol.2023.01.010
dc.identifier.urihttps://hdl.handle.net/11454/102098
dc.identifier.volume54en_US
dc.identifier.wosWOS:000963392200001en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.relation.ispartofPhytochemistry Lettersen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmz20240825_Gen_US
dc.subjectTeucrium divaricatum subspen_US
dc.subjectdivaricatumen_US
dc.subjectLamiaceaeen_US
dc.subjectneo-clerodaneen_US
dc.subjectAntimicrobialen_US
dc.subjectiNOSen_US
dc.subjectNeoclerodane Diterpenoidsen_US
dc.subjectFuranoid Diterpenesen_US
dc.subjectChamaedrysen_US
dc.subjectPhytochemistryen_US
dc.subjectGlucosideen_US
dc.subjectC-12en_US
dc.titleneo-Clerodanes from Teucrium divaricatum subsp. divaricatum and their biological activity assessmenten_US
dc.typeArticleen_US

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