Nifedipine induces expansive vascular remodeling of carotid arteries in rabbit collar model [Nifedipin tavşan yaka modelinde karotid arterlerin dişa dogru vasküler yeniden modellenmesine yol açar]

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dc.contributor.authorReel B.
dc.contributor.authorErgür B.U.
dc.date.accessioned2019-10-27T08:34:14Z
dc.date.available2019-10-27T08:34:14Z
dc.date.issued2011
dc.departmentEge Üniversitesien_US
dc.description.abstractObjective: Intimal thickening is an adaptive response to injury and to stimuli acting on the vessel wall. Vascular remodeling (VR) is defined as the changes in the size and/or composition of the vessels in response to dynamic and trophic stimuli. Inappropriate VR plays a crucial role in lumen loss and pathogenesis of cardiovascular diseases. Calcium channel blockers (CCBs) have been known to have vascular protective effects. However, the precise molecular mechanisms of these effects have not been fully elucidated. The aim of this study was to investigate the effects of nifedipine on intimal thickening and pathological VR, and to examine the role of the discoidin domain receptors (DDRs), which are collagen receptors, in the VR process in the collar model. Material and Methods: White rabbits were randomized into two groups. The groups received vehicle or nifedipine (40 mg/kg/day, p.o.) for three weeks. After seven days, a non-occlusive silicone collar was placed around the left carotid artery. To evaluate intimal thickening and VR, the intimal area, medial and luminal perimeters were measured. Furthermore, DDR expressions were assessed immunohistochemically. Results: Nifedipine did not inhibit intimal thickening. The collar provoked inward VR. Neither collagen content nor DDR expressions were affected by the collar. Nifedipine constituted hypertrophic outward expansive VR by involving luminal and arterial enlargement. However nifedipine did not change either collagen ingredient or DDR expressions. Conclusion: Ni- fedipine did not inhibit intimal thickening. However, it resulted in favorable expansive VR without changing collagen contents and DDR expressions. Thus, nifedipine may help to maintain luminal patency and to prevent restenosis after balloon angioplasty. © 2011 by Türkiye Klinikleri.en_US
dc.identifier.doi10.5336/medsci.2009-16049
dc.identifier.endpage85en_US
dc.identifier.issn1300-0292
dc.identifier.issn1300-0292en_US
dc.identifier.issue1en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage75en_US
dc.identifier.urihttps://doi.org/10.5336/medsci.2009-16049
dc.identifier.urihttps://hdl.handle.net/11454/27002
dc.identifier.volume31en_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherTurkiye Kliniklerien_US
dc.relation.ispartofTurkiye Klinikleri Journal of Medical Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAtherosclerosisen_US
dc.subjectCalcium channel blockersen_US
dc.subjectDiscoidin receptoren_US
dc.subjectRabbitsen_US
dc.subjectVascular patencyen_US
dc.titleNifedipine induces expansive vascular remodeling of carotid arteries in rabbit collar model [Nifedipin tavşan yaka modelinde karotid arterlerin dişa dogru vasküler yeniden modellenmesine yol açar]en_US
dc.typeArticleen_US

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