Evaluation of the antinociceptive and anti-inflammatory activities of Satureja thymbra L. essential oil

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dc.contributor.authorKarabay-Yavasoglu, N. Ulku
dc.contributor.authorBaykan, Sura
dc.contributor.authorOzturk, Bintug
dc.contributor.authorApaydin, Sebnem
dc.contributor.authorTuglular, Isik
dc.date.accessioned2019-10-27T19:40:42Z
dc.date.available2019-10-27T19:40:42Z
dc.date.issued2006
dc.departmentEge Üniversitesien_US
dc.description.abstractThe aim of this study was to investigate the antinociceptive and anti-inflammatory activities of the essential oil of Satureja thymbra L. (Lamiaceae). Antinociceptive activity of the essential oil was measured by the formalin test in mice and by the light tail-flick and hot-plate methods in rats. The paw-edema test was performed in rats to evaluate the anti-inflammatory effect of the essential oil. Motor coordination was assessed with a rotarod apparatus. Although the essential oil produced an antinociceptive effect during both the early (50 and 100 mg kg(-1)) and late phases (25, 50, and 100 mg kg(-1)) of the formalin test, it did not exert any significant antinociceptive and anti-inflammatory effects in tail-flick and paw-edema tests, respectively. In addition, a significant antinociceptive effect was detected in the hot-plate test (100 and 200 mg kg(-1)). No significant change was detected in sensory motor performance. In conclusion, S. thymbra L. essential oil does not exert any anti-inflammatory effect while it may have central analgesic activity in mice and rats.en_US
dc.identifier.doi10.1080/13880200600896827
dc.identifier.endpage591en_US
dc.identifier.issn1388-0209
dc.identifier.issn1744-5116
dc.identifier.issn1388-0209en_US
dc.identifier.issn1744-5116en_US
dc.identifier.issue8en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage585en_US
dc.identifier.urihttps://doi.org/10.1080/13880200600896827
dc.identifier.urihttps://hdl.handle.net/11454/40285
dc.identifier.volume44en_US
dc.identifier.wosWOS:000241854400005en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofPharmaceutical Biologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectanti-inflammatoryen_US
dc.subjectantinociceptiveen_US
dc.subjectessential oilen_US
dc.subjectmiceen_US
dc.subjectraten_US
dc.subjectSatureja thymbra L.en_US
dc.titleEvaluation of the antinociceptive and anti-inflammatory activities of Satureja thymbra L. essential oilen_US
dc.typeArticleen_US

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