Systematic review on recent potential biomarkers of chronic obstructive pulmonary disease

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dc.contributor.authorAydindogan, Eda
dc.contributor.authorPenque, Deborah
dc.contributor.authorZoidakis, Jerome
dc.date.accessioned2019-10-27T09:59:15Z
dc.date.available2019-10-27T09:59:15Z
dc.date.issued2019
dc.departmentEge Üniversitesien_US
dc.description.abstractIntroduction: Chronic obstructive pulmonary disease (COPD) is one of the leading causes of death worldwide and associated with decreased lung function and inflammation. The heterogeneity of COPD and its molecular and clinical features hinder efficient patient stratification and introduction of personalized therapeutic approaches. The available clinical tools do not efficiently predict the progression and exacerbations of the disease. Areas covered: An overview of the most recent studies on putative COPD protein biomarkers and the challenges for implementing their use in the clinical setting is presented. Expert commentary: Proteomics biomarker discovery in COPD has mostly focused on approaches evaluating specific proteins on a limited number of samples. The most promising protein candidates can be classified into five main biological categories: extracellular matrix (ECM) remodeling, inflammation/immune response, oxidative stress response, vascular tone regulation, and lipid metabolism. To efficiently stratify COPD patients and predict exacerbations, it will be necessary to implement biomarker panels to better represent the complex pathophysiology of this disease. The application of unbiased proteomics and bioinformatics followed by appropriate clinical validation studies will contribute to the achievement of this aim while increasing the number of validated biomarkers that can enter the qualification processes by the regulatory entities.en_US
dc.identifier.doi10.1080/14737159.2018.1559054
dc.identifier.endpage45en_US
dc.identifier.issn1473-7159
dc.identifier.issn1744-8352
dc.identifier.issn1473-7159en_US
dc.identifier.issn1744-8352en_US
dc.identifier.issue1en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage37en_US
dc.identifier.urihttps://doi.org/10.1080/14737159.2018.1559054
dc.identifier.urihttps://hdl.handle.net/11454/29592
dc.identifier.volume19en_US
dc.identifier.wosWOS:000456383200002en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Asen_US
dc.relation.ispartofExpert Review of Molecular Diagnosticsen_US
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectProtein biomarkersen_US
dc.subjectproteomicsen_US
dc.subjectbiomarkersen_US
dc.subjectCOPDen_US
dc.subjectexacerbationsen_US
dc.subjectmortalityen_US
dc.titleSystematic review on recent potential biomarkers of chronic obstructive pulmonary diseaseen_US
dc.typeReview Articleen_US

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