Isolation and characterization of biologically active glycosides from endemic Cephalaria species in Anatolia

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dc.contributor.authorSarikahya, Nazli Boke
dc.contributor.authorPekmez, Murat
dc.contributor.authorArda, Nazli
dc.contributor.authorKayce, Peyker
dc.contributor.authorYavasoglu, N. Ulku Karabay
dc.contributor.authorKirmizigul, Suheyla
dc.date.accessioned2019-10-27T21:35:22Z
dc.date.available2019-10-27T21:35:22Z
dc.date.issued2011
dc.departmentEge Üniversitesien_US
dc.description.abstractChemical constituents of the aerial parts of four endemic Cephalaria species (Dipsacaceae) in Anatolia, C. scoparia, C. paphlagonica, C. isaurica and C. stellipilis, were investigated. Two new triterpene glycosides from C. scoparia, namely scoposides F (1) and G (2), along with 11 known compounds including phenolic, flavonoid, iridoid and triterpene-type glycosides were isolated from these species. The structures of all compounds were elucidated on the basis of spectroscopic data and chemical evidence. Antioxidant activity of the compounds was tested with CUPRAC method for the first time in addition to the DPPH by using trolox and ascorbic acid as reference antioxidants, respectively. The antimicrobial activity was assessed by MIC assay and the results were given as MIC (mu g/mL) values. New triterpene glycosides scoposides F-G (1 and 2) and the compounds paphlagonoside A (6), paphlagonoside B (7) and isacoside (9), which were not tested previously, exhibited as strong antibacterial activity against Gram (+) and Gram ( ) bacteria. (C) 2011 Phytochemical Society of Europe. Published by Elsevier B. V. All rights reserved.en_US
dc.description.sponsorshipTUBITAKTurkiye Bilimsel ve Teknolojik Arastirma Kurumu (TUBITAK) [107T028]; EBILTEMEge University [2008BIL003]; Research Grant Office of Ege UniversityEge University [2009FEN080]en_US
dc.description.sponsorshipThis work was supported by TUBITAK (107T028), EBILTEM (2008BIL003) and Research Grant Office of Ege University (2009FEN080). TUBITAK, EBILTEM and Izmir Hygiene Institute are gratefully acknowledged for providing HR-ESI/MS, NMR (400 MHz) spectra and GC-MS analysis, respectively. Thanks are also due to H. Sumbul and R.S. Gokturk for their valuable assistance for collection and identification of the plant materials.en_US
dc.identifier.doi10.1016/j.phytol.2011.05.006
dc.identifier.endpage420en_US
dc.identifier.issn1874-3900
dc.identifier.issn1874-3900en_US
dc.identifier.issue4en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage415en_US
dc.identifier.urihttps://doi.org/10.1016/j.phytol.2011.05.006
dc.identifier.urihttps://hdl.handle.net/11454/45846
dc.identifier.volume4en_US
dc.identifier.wosWOS:000297321800007en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherElsevier Science Bven_US
dc.relation.ispartofPhytochemistry Lettersen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectDipsacaceaeen_US
dc.subjectCephalariaen_US
dc.subjectScoposides F-Gen_US
dc.subjectTriterpene glycosideen_US
dc.subjectAntimicrobial activityen_US
dc.subjectAntioxidant activityen_US
dc.titleIsolation and characterization of biologically active glycosides from endemic Cephalaria species in Anatoliaen_US
dc.typeArticleen_US

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