Labeling of apigenin with I-131 and bioactivity of I-131-apigenin in male and female rats

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dc.contributor.authorSeyitoglu, B.
dc.contributor.authorLambrecht, F. Yurt
dc.contributor.authorDurkan, K.
dc.date.accessioned2019-10-27T20:19:14Z
dc.date.available2019-10-27T20:19:14Z
dc.date.issued2009
dc.departmentEge Üniversitesien_US
dc.description.abstractApigenin (4',5,7-trihydroxyflavone), one of the most common flavonoids, has been shown to possess a variety of biological activities including tumor growth inhibition and chemopreventation. In the present study, apigenin was labeled with I-131 using iodogen method and investigated of its bioactivity. Radiolabeling yield is 98 +/- 0.2%, as determined by radio thin layer chromatography (RTLC), electrophoresis and radio high performance liquid chromatography (RHPLC). Besides, structure analysis of synthesized cold iodoapigenin complex were assessed with LCMS/MS and H-1-NMR. Results of in vitro study indicated a high stability (3 hours) in human serum. Biodistrubition studies are performed in male and female albino Wistar rats. Biodistribution data related to the male rats showed significant uptake in the small intestine. The female rats biodistribution results indicated that the uptake of I-131-apigenin was high in the intestine and uterus.en_US
dc.identifier.doi10.1007/s10967-008-7401-6
dc.identifier.endpage873en_US
dc.identifier.issn0236-5731
dc.identifier.issn0236-5731en_US
dc.identifier.issue3en_US
dc.identifier.startpage867en_US
dc.identifier.urihttps://doi.org/10.1007/s10967-008-7401-6
dc.identifier.urihttps://hdl.handle.net/11454/41369
dc.identifier.volume279en_US
dc.identifier.wosWOS:000263978300025en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofJournal of Radioanalytical and Nuclear Chemistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.titleLabeling of apigenin with I-131 and bioactivity of I-131-apigenin in male and female ratsen_US
dc.typeArticleen_US

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