Antibacterial properties of subphthalocyanine and subphthalocyanine-TiO2 nanoparticles on Staphylococcus aureus and Escherichia coli

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dc.contributor.authorOzturk, Ismail
dc.contributor.authorTuncel, Ayga
dc.contributor.authorInce, Mine
dc.contributor.authorOcakoglu, Kasim
dc.contributor.authorHosgor-Limoncu, Mine
dc.contributor.authorYurt, Fatma
dc.date.accessioned2019-10-27T09:59:51Z
dc.date.available2019-10-27T09:59:51Z
dc.date.issued2018
dc.departmentEge Üniversitesien_US
dc.description.abstractNowadays the problem of antimicrobial resistance is the most important cause of morbidity and mortality in the treatment of infectious diseases worldwide. Treatment options for antimicrobial-resistant microorganisms are quite limited. Therefore, alternative treatment strategies are needed to control infectious diseases. Antimicrobial photodynamic therapy (aPDT) is one of the new treatment modalities proposed for a wide variety of infections. In the basic principle of aPDT, photosensitizers (PS) produce free radicals by irradiating them with harmless light at the appropriate wavelength, and this causes microorganism cell cytotoxicity. In this study, light emitting diodes (LED) (630-700 nm, 17.4 mW/cm(2)) were used on Gram-positive Staphylococcus aureus (S. aureus) and Gram-negative Escherichia coli (E. coli) at different light doses under the minimum inhibitory concentration (MIC) values of SubPc and SubPc-integrated TiO2 nanoparticles (SubPc-TiO2) concentration. Both compounds show good phototoxicity toward S. aureus when high light doses (16, 24 J/cm(2)) were applied. In addition, SubPc-TiO2 were found to be more effective than SubPc in aPDT of S. aureus. In E. coli, the success of aPDT has been shown to be dependent on the increased light dose (20, 30 J/cm(2) ) for both compounds. As a result, the aPDT activity of SubPc-TiO2 is more effective than SubPc in increasing light doses.en_US
dc.description.sponsorshipEge University Scientific Research Projects (BAP) commission [18 NBE 003]en_US
dc.description.sponsorshipThis work was supported by the Ege University Scientific Research Projects (BAP) commission with 18 NBE 003 project code.en_US
dc.identifier.doi10.1142/S1088424618501122
dc.identifier.endpage1105en_US
dc.identifier.issn1088-4246
dc.identifier.issn1099-1409
dc.identifier.issn1088-4246en_US
dc.identifier.issn1099-1409en_US
dc.identifier.issue12en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage1099en_US
dc.identifier.urihttps://doi.org/10.1142/S1088424618501122
dc.identifier.urihttps://hdl.handle.net/11454/29680
dc.identifier.volume22en_US
dc.identifier.wosWOS:000453779800008en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherWorld Sci Publ Co Incen_US
dc.relation.ispartofJournal of Porphyrins and Phthalocyaninesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectantimicrobial photodynamic therapyen_US
dc.subjectsubphthalocyanineen_US
dc.subjectTiO2 nanoparticlesen_US
dc.subjectStaphylococcus aureusen_US
dc.subjectEscherichia colien_US
dc.titleAntibacterial properties of subphthalocyanine and subphthalocyanine-TiO2 nanoparticles on Staphylococcus aureus and Escherichia colien_US
dc.typeArticleen_US

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