ELECTROSPUN THERMOPLASTIC POLYURETHANE MATS CONTAINING NAPROXEN-CYCLODEXTRIN INCLUSION COMPLEX

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dc.contributor.authorAkduman, Cigdem
dc.contributor.authorOzguney, Isik
dc.contributor.authorKumbasar, E. Perrin Akcakoca
dc.date.accessioned2019-10-27T22:12:25Z
dc.date.available2019-10-27T22:12:25Z
dc.date.issued2014
dc.departmentEge Üniversitesien_US
dc.description.abstractIncorporation of cyclodextrins (CDs) into electrospun nanofibrous materials can be considered as potential candidates for functional medical textile applications. Naproxen (NAP) is a type of non-steroidal anti-inflammatory drug commonly administered for the treatment of pain, inflammation and fever. Drug-inclusion complex formation with CDs is an approach to improve the aqueous solubility via molecular encapsulation of the drug within the cavity of the more soluble CD molecule. In this study, NAP or different NAP-CD inclusion complexes loaded nanofibres were successfully produced through electrospinning and characterised. The inclusion complex loaded mats exhibited significantly faster release profiles than NAP-loaded thermoplastic polyurethane (TPU) mats. Overall, NAP-inclusion complex loaded TPU electrospun nanofibres could be used as drug delivery systems for acute pain treatments since they possess a highly porous structure that can release the drug immediately.en_US
dc.description.sponsorshipResearch Foundation of Ege UniversityEge University [13 MUH 051]en_US
dc.description.sponsorshipThe authors acknowledge Research Foundation of Ege University for the financial support given to this study (Project number: 13 MUH 051) and to Scientific Research Projects of Pamukkale University for support given for symposium registration fee. The authors also thank "the Pharmaceutical Sciences Research Centre, Faculty of Pharmacy, Ege University".en_US
dc.identifier.doi10.2478/aut-2014-0024
dc.identifier.endpage246en_US
dc.identifier.issn1470-9589
dc.identifier.issn2300-0929
dc.identifier.issue4en_US
dc.identifier.startpage239en_US
dc.identifier.urihttps://doi.org/10.2478/aut-2014-0024
dc.identifier.urihttps://hdl.handle.net/11454/49423
dc.identifier.volume14en_US
dc.identifier.wosWOS:000346705900004en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.language.isoenen_US
dc.publisherAutexen_US
dc.relation.ispartofAutex Research Journalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectNaproxenen_US
dc.subjectbeta-cyclodextrinen_US
dc.subject2-hydroxy propyl-beta-CDen_US
dc.subjectInclusion complexen_US
dc.subjectElectrospinningen_US
dc.subjectDrug releaseen_US
dc.titleELECTROSPUN THERMOPLASTIC POLYURETHANE MATS CONTAINING NAPROXEN-CYCLODEXTRIN INCLUSION COMPLEXen_US
dc.typeArticleen_US

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