CELL INCORPORATION STUDY OF [99mTc]Tc-NAB-PACLITAXEL ON HUMAN COLORECTAL ADENOCARCINOMA CELL LINE

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dc.authorscopusid56661951100
dc.authorscopusid55748265800
dc.contributor.authorEkıncı M.
dc.contributor.authorİlem-Özdemır D.
dc.date.accessioned2023-01-12T20:26:09Z
dc.date.available2023-01-12T20:26:09Z
dc.date.issued2022
dc.departmentN/A/Departmenten_US
dc.description.abstractObjective: The development of new radiopharmaceuticals capable of specifically imaging cancer is an important research area. For this reason, the aim of this study is to investigate cell binding of novel developed nanoradiopharmaceutical ([99mTc]Tc-nab-PTX) on HT-29 cell line (human colorectal adenocarcinoma cells). Material and Method: In this study, nab-PTX was labeled with [99mTc]Tc, and labeling efficiency and in vitro stability were investigated by radioactive thin layer chromatography (RTLC). Then, cell incorporation of [99mTc]Tc-nab-PTX was performed using HT-29 cell line. Result and Discussion: According to obtained results, nab-PTX was labeled with high radiochemical purity (>99%). The [99mTc]Tc-nab-PTX was found to be stable in saline for 6-h, and in cell medium up to 2-h. It was determined that [99mTc]Tc-nab-PTX had a greater cell binding activity on HT-29 cells than R/H-[99mTc]NaTcO4 at 30 min. The results were found to be promising for future in vivo studies with [99mTc]Tc-nab-PTX. © 2022 University of Ankara. All rights reserved.en_US
dc.description.sponsorshipThe authors thank to Ege University Nuclear Medicine Department for obtaining [99mTc]Tc and to Prof. Dr. Emel Öykü Çetin Uyanıkgil for providing cell line.en_US
dc.identifier.doi10.33483/jfpau.1166949
dc.identifier.issn10153918
dc.identifier.issn1015-3918en_US
dc.identifier.issue1en_US
dc.identifier.scopus2-s2.0-85145337199en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.urihttps://doi.org/10.33483/jfpau.1166949
dc.identifier.urihttps://hdl.handle.net/11454/79909
dc.identifier.volume47en_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherUniversity of Ankaraen_US
dc.relation.ispartofAnkara Universitesi Eczacilik Fakultesi Dergisien_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectHT29 cell lineen_US
dc.subjectnab-paclitaxelen_US
dc.subjectradiolabelingen_US
dc.subjecttechnetium-99men_US
dc.titleCELL INCORPORATION STUDY OF [99mTc]Tc-NAB-PACLITAXEL ON HUMAN COLORECTAL ADENOCARCINOMA CELL LINEen_US
dc.title.alternative[99mTc]Tc-NAB-PAKLİTAKSEL'İN İNSAN KOLOREKTAL ADENOKARSİNOMA HÜCRE HATTI ÜZERİNDE HÜCRE BAĞLANMA ÇALIŞMASIen_US
dc.typeArticleen_US

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