First Report and in Silico Analysis of Leishmania virus (LRV2) identified in an autochthonous Leishmania major isolate in Turkey

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dc.contributor.authorKurt Ö.
dc.contributor.authorMansur N.
dc.contributor.authorÇavuş I.
dc.contributor.authorÖzcan O.
dc.contributor.authorBurak Batir M.
dc.contributor.authorGündüz C.
dc.contributor.authorSezerman U.
dc.contributor.authorÖzbilgın A.
dc.date.accessioned2019-10-26T21:13:32Z
dc.date.available2019-10-26T21:13:32Z
dc.date.issued2019
dc.departmentEge Üniversitesien_US
dc.description.abstractLeishmania virus (LRV) has previously been identified in different Leishmania species. Host-LRV interaction is associated with exacerbated clinical manifestations of cutaneous leishmaniasis (CL) and may cause poor therapeutic response. CL cases due to L. major with large skin lesions resistant to routine therapy were recently identified in Turkey. Here, we report the first autochthonous case of cutaneous leishmaniasis caused by LRV-positive Leishmania major, using conventional PCR targeting the viral capsid protein of LRV. The lesion of the case was 6 months old, relatively large (4 cm), and did not recover despite three consecutive intralesional applications of glucantime. Assessment of LRV’s influence on prognosis and clinical outcomes of leishmaniasis, based on additional studies, is required. ©2019 by EDIMES - Edizioni Internazionali Srl. All rights reserveden_US
dc.identifier.endpage67en_US
dc.identifier.issn1121-7138
dc.identifier.issn1121-7138en_US
dc.identifier.issue1en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage64en_US
dc.identifier.urihttps://hdl.handle.net/11454/15790
dc.identifier.volume42en_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherLuigi Ponzio e figlio Editorien_US
dc.relation.ispartofNew Microbiologicaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCutaneous leishmaniasisen_US
dc.subjectIn Silico analysisen_US
dc.subjectLeishmania majoren_US
dc.subjectLeishmania Virus (LRV)en_US
dc.subjectTurkeen_US
dc.titleFirst Report and in Silico Analysis of Leishmania virus (LRV2) identified in an autochthonous Leishmania major isolate in Turkeyen_US
dc.typeArticleen_US

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