Antiproliferative activity of some tautomeric hydrazones derived from chalcones [Şalkonlardan hareketle elde edilen bazı tautomerik hidrazonların antiproliferatif aktiviteleri]

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dc.contributor.authorTok F.
dc.contributor.authorBeyhan N.
dc.contributor.authorErzurumlu Y.
dc.contributor.authorİlhan R.
dc.contributor.authorBallar P.
dc.contributor.authorKocyıgıt-Kaymakcıoglu B.
dc.date.accessioned2019-10-27T08:20:53Z
dc.date.available2019-10-27T08:20:53Z
dc.date.issued2016
dc.departmentEge Üniversitesien_US
dc.description.abstractA new series of hydrazones synthesized from chalcones. Synthesized compounds have been characterized by IR, 1H-NMR and elemental analysis. Antiproliferative activity of compounds was investigated on Hela, A549, MC F7, HCC 1937, MRC 5 cells. All compounds exhibited cytotoxicity. Especially compounds 1b, 1c, 1f and 1i having 4-metylsulfonyl phenyl showed higher cytotoxicity against all of the cell lines compared to reference drug doxorubicin with low value of IC50=5.56-21.93 µM. The most active compounds 1b, 1c, 1f and 1i were analyzed for their effect on autophagic processes. HCC 1937 cells were treated with these compounds at IC50 concentration for 24 hours. An immunoblotting assay was performed to analysis autophagy markers and total polyubiquitinated protein levels. Compounds 1b, 1c, 1f and 1i significantly increased the conversion of LC 3-I to LC 3-II at IC50 concentration. None of the tested compounds changed the level of total polyubiquitinated proteins. © 2016, Marmara University. All Rights Reserved.en_US
dc.identifier.doi10.12991/mpj.20162093956
dc.identifier.endpage163en_US
dc.identifier.issn1309-0801
dc.identifier.issn1309-0801en_US
dc.identifier.issue2en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage157en_US
dc.identifier.urihttps://doi.org/10.12991/mpj.20162093956
dc.identifier.urihttps://hdl.handle.net/11454/25842
dc.identifier.volume20en_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherMarmara Universityen_US
dc.relation.ispartofMarmara Pharmaceutical Journalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAntiproliferative activityen_US
dc.subjectChalconesen_US
dc.subjectHydrazonesen_US
dc.titleAntiproliferative activity of some tautomeric hydrazones derived from chalcones [Şalkonlardan hareketle elde edilen bazı tautomerik hidrazonların antiproliferatif aktiviteleri]en_US
dc.typeArticleen_US

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