Phlomis species protects the cells from oxidative stress by upregulating catalase enzyme expression

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dc.authorscopusid57195953961
dc.authorscopusid57221232305
dc.authorscopusid36113162500
dc.authorscopusid25935885100
dc.authorscopusid6701349394
dc.contributor.authorTastan, Pelin
dc.contributor.authorBirim, Dervis
dc.contributor.authorFafal, Tugce
dc.contributor.authorArmagan, Guliz
dc.contributor.authorKivcak, Bijen
dc.date.accessioned2023-01-12T20:19:21Z
dc.date.available2023-01-12T20:19:21Z
dc.date.issued2022
dc.departmentN/A/Departmenten_US
dc.description.abstractRecently, interest in the pharmacological effects of plants has increased and studies on bioactive compounds have intensified. In this study, we aimed at evaluating the antioxidant and neuroprotective potential of Lamiaceae plants including Stachys lavandulifolia, Salvia verticillata, Phlomis herba venti sp. pungens and Phlomis sieheana in both cellfree systems and the cell culture model. Methanol extracts of the aerial parts of these plants, cultivated in Elazig, Turkey were carried out. Antioxidant activity assays (ABTS and DPPH) and total phenolic and flavonoid contents of the extracts were measured. Next, the effects of methanol extracts on cell viability and catalase protein levels were investigated in hydrogen peroxide induced oxidative stress model. DPPH radical scavenging activities were determined with the IC50 value of 31.36 +/- 0.25, 30.44 +/- 0.19, 30.16 +/- 0.08 and 56.54 +/- 0.93 for Stachys lavandulifolia, Salvia verticillata, Phlomis herba venti sp. pungens and Phlomis sieheana, respectively. ABTS radical scavenging activities were determined as 6.38 +/- 1.48, 16.93 +/- 0.68, 5.97 +/- 4.04 and 2.28 +/- 0.51. The highest cellular protection and catalase expression were determined in Phlomis-treated cells against H2O2 (p<0.05). On the other hand, no statistically significant change in cell viability was observed when the extracts were compared with each other. Our findings support the neuroprotective and antioxidant potential of these four Lamiaceae plants, particularly Phlomis species.en_US
dc.description.sponsorshipEge University Scientific Research Projects Coordination Unit [20575]en_US
dc.description.sponsorshipThis research was supported by Ege University Scientific Research Projects Coordination Unit. Project Number: 20575.en_US
dc.identifier.endpage56en_US
dc.identifier.issn0035-6808
dc.identifier.issn0035-6808en_US
dc.identifier.issue1en_US
dc.identifier.scopus2-s2.0-85129814081en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage49en_US
dc.identifier.urihttps://hdl.handle.net/11454/79104
dc.identifier.volume99en_US
dc.identifier.wosWOS:000798950500006en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.language.isoenen_US
dc.publisherInnovhub Ssi-Area Ssogen_US
dc.relation.ispartofRivista Italiana Delle Sostanze Grasseen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectPhlomisen_US
dc.subjectSalviaen_US
dc.subjectStachysen_US
dc.subjectantioxidanten_US
dc.subjectcell cultureen_US
dc.subjectEssential Oil Compositionen_US
dc.subjectStachys-Lavandulifolia Vahl.en_US
dc.subjectAntioxidant Activityen_US
dc.subjectSalvia-Verticillataen_US
dc.subjectChemical-Compositionen_US
dc.subjectPhenolic-Compoundsen_US
dc.subjectFlavonoid Contenten_US
dc.subjectMedicinal-Plantsen_US
dc.subjectMountain Teaen_US
dc.subjectFlowersen_US
dc.titlePhlomis species protects the cells from oxidative stress by upregulating catalase enzyme expressionen_US
dc.typeArticleen_US

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