Preparation and characterization of radiolabeled magnetic nanoparticles as an imaging agent

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dc.contributor.authorIçhedef C.
dc.contributor.authorTeksöz S.
dc.contributor.authorÜnak P.
dc.contributor.authorMedine E.I.
dc.contributor.authorErtay T.
dc.contributor.authorBekiş R.
dc.date.accessioned2019-10-26T21:46:05Z
dc.date.available2019-10-26T21:46:05Z
dc.date.issued2012
dc.departmentEge Üniversitesien_US
dc.description.abstractMagnetic nanoparticles were prepared by a reduction-precipitation method and coated with an amino silane coupling agent. Guanine (Gua) was conjugated to the magnetic nanoparticles (MNPs) using glutaraldehyde as a cross-linker. Common techniques (Fourier transform infrared spectroscopy, scanning electron microscopy, X-ray diffraction, and vibrating electron microscopy) were used to assess the properties of the particles. Structural investigations showed that amino silane-coated MNPs had a particle size of about 40-60 nm in diameter with a spherical morphology. The guanine-conjugated MNPs were radiolabeled with 99mTc(I)-tricarbonyl core ( 99mTc(CO) 3-MNP-Gua) with a labeling yield of 72 ± 4 %. Pure radiolabeled magnetic particles were obtained by washing them with saline solution, and the radiochemical purity of 99mTc(CO) 3-MNP-Gua was 98 ± 2 % in the final solution. The biologic distribution of guanine MNPs was assessed in New Zealand rabbits using a gamma camera. In the in vivo experiment, a high level of radioactivity was observed in the lungs and liver soon after intravenous administration of 99mTc(CO) 3-MNP-Gua. © 2012 Springer Science+Business Media B.V.en_US
dc.description.sponsorshipFirat University Scientific Research Projects Management Unit: 2007NBE003en_US
dc.description.sponsorshipAcknowledgment This study was financially supported by the Ege University Scientific Research Project numbered 2007NBE003, (Bornova Izmir, Turkey). --en_US
dc.identifier.doi10.1007/s11051-012-1077-0
dc.identifier.issn1388-0764
dc.identifier.issn1388-0764en_US
dc.identifier.issue8en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://doi.org/10.1007/s11051-012-1077-0
dc.identifier.urihttps://hdl.handle.net/11454/18540
dc.identifier.volume14en_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.relation.ispartofJournal of Nanoparticle Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectGuanineen_US
dc.subjectImagingen_US
dc.subjectMagnetic nanoparticlesen_US
dc.subjectTechnetium tricarbonyl coreen_US
dc.titlePreparation and characterization of radiolabeled magnetic nanoparticles as an imaging agenten_US
dc.typeArticleen_US

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