Protoporphyrin-IX and Manganese Oxide Nanoparticles Encapsulated in Niosomes as Theranostic

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dc.contributor.authorOzada, Cagatay
dc.contributor.authorTekin, Volkan
dc.contributor.authorBarlas, F. Baris
dc.contributor.authorTimur, Suna
dc.contributor.authorUnak, Perihan
dc.date.accessioned2020-12-01T12:02:30Z
dc.date.available2020-12-01T12:02:30Z
dc.date.issued2020
dc.departmentEge Üniversitesien_US
dc.description.abstractPurpose of this study is to develop a multifunctional theranostic agent for both imaging (MR and fluorescence) and combined therapy (photodynamic and radiotherapy). Initially, manganese oxide nanoparticles (MnO NPs) were synthesized and conjugated with diethylenetriaminepentaacetic acid (DTPA) which will be then called as MnO-DTPA NPs, and at the final step, synthesized MnO NPs were encapsulated with niosomes in the presence of protoporphyrin-IX (PP(IX)). in vitro cell culture and bioaffinity studies were performed on PC-3 and BJ cells. the structures (Niosome-MnO-DTPA-PP(IX)) have fluorescence properties and photodynamic therapy potential due to the presence of PP(IX) as well as MR imaging and photodynamic and radiotherapy efficiency. According to data, it was claimed that toxicity of MnO NPs were significantly decreased after encapsulation of niosomes especially for BJ cell line. Therapy potential of the 'Niosome-MnO-DTPA-PP(IX)' was examined and promising findings were obtained for the potential use of combined therapy agent for prostate cancer cells.en_US
dc.description.sponsorshipEge University Research FoundationEge University [18 FBE 006]en_US
dc.description.sponsorshipThis work was supported by Ege University Research Foundation (18 FBE 006). SPM analysis was performed at Ege University Central Research Test and Analysis Laboratory the Research Center (Ege MATAL). Also, this work has been partially presented at 4th International Symposium on Composite Materials (KOMPEGE 2018), 6-8 September 2018, Izmir-Turkey. the authors would like to thank Mr Yasakci for his contribution to the editing of the Figures.en_US
dc.identifier.doi10.1002/slct.201901620
dc.identifier.endpage1993en_US
dc.identifier.issn2365-6549
dc.identifier.issn2365-6549en_US
dc.identifier.issue6en_US
dc.identifier.scopus2-s2.0-85079733479en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage1987en_US
dc.identifier.urihttps://doi.org/10.1002/slct.201901620
dc.identifier.urihttps://hdl.handle.net/11454/62693
dc.identifier.volume5en_US
dc.identifier.wosWOS:000513245800026en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.language.isoenen_US
dc.publisherWiley-V C H Verlag Gmbhen_US
dc.relation.ispartofChemistryselecten_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectNiosomesen_US
dc.subjectmanganese oxide nanoparticlesen_US
dc.subjectMRIen_US
dc.subjectPhotodynamic therapyen_US
dc.subjectRadiotherapyen_US
dc.titleProtoporphyrin-IX and Manganese Oxide Nanoparticles Encapsulated in Niosomes as Theranosticen_US
dc.typeArticleen_US

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