In vitro cytotoxic and anti-inflammatory activities of tanacetum argenteum (lam.) willd. subsp. argenteum extract [Tanacetum argenteum subsp. argenteum Ekstrelerinin in vitro sitotoksik ve anti-inflamatuvar etkileri]

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dc.contributor.authorAlbayrak G.
dc.contributor.authorNalbantsoy A.
dc.contributor.authorBaykan Ş.
dc.date.accessioned2019-10-27T08:03:15Z
dc.date.available2019-10-27T08:03:15Z
dc.date.issued2017
dc.departmentEge Üniversitesien_US
dc.description.abstractObjectives: The objective of this study was to examine the anti-inflammatory and cytotoxic potential of n-hexane, ethyl acetate, and methanolic extracts of Tanacetum argenteum subsp. argenteum. Materials and Methods: Tanacetum L. is the third largest genus of Asteraceae family and is represented by 60 taxa in Turkish flora. Sesquiterpene lactones and pyrethrins are the main chemical groups of the genus. T. argenteum subsp. argenteum is an endemic taxa that is distributed in the Central and South Anatolia. Results: In vitro anti-inflammatory activity was assayed using iNOS and NF-?B inhibition tests on RAW264.7 and HeLa cells. The cytotoxic activities were tested against ten cell lines using MTT assays. Conclusion: As a result, the n-hexane extract was found more active than the positive control parthenolide in iNOS test (IC50: 0.627±0.16 µg/mL) and cytotoxic experiments against PC3 and MPANC-96 cell lines (IC50: 2.85±0.51 µg/mL and 5.35±1.24 µg/mL, respectively). © Turk J Pharm Sci, Published by Galenos Publishing House.en_US
dc.identifier.doi10.4274/tjps.42714
dc.identifier.endpage236en_US
dc.identifier.issn1304530X
dc.identifier.issn1304-530Xen_US
dc.identifier.issue3en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage231en_US
dc.identifier.urihttps://doi.org/10.4274/tjps.42714
dc.identifier.urihttps://hdl.handle.net/11454/25328
dc.identifier.volume14en_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherTurkish Pharmacists Associationen_US
dc.relation.ispartofTurkish Journal of Pharmaceutical Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAnti-inflammatoryen_US
dc.subjectCytotoxicityen_US
dc.subjectInosen_US
dc.subjectMTTen_US
dc.subjectNF-?Ben_US
dc.subjectTanacetum argenteum subsp. argenteumen_US
dc.titleIn vitro cytotoxic and anti-inflammatory activities of tanacetum argenteum (lam.) willd. subsp. argenteum extract [Tanacetum argenteum subsp. argenteum Ekstrelerinin in vitro sitotoksik ve anti-inflamatuvar etkileri]en_US
dc.typeArticleen_US

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