Tetrachloromethane Induced Acute Liver Injury in Mice: Biochemical and Histopathological Study of the Hepatoprotective Effect of Hep-X Standardized Botanical Dietary Supplement

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dc.authorscopusid58147202300
dc.authorscopusid55390606700
dc.authorscopusid56376463500
dc.authorscopusid6507731451
dc.authorscopusid58147599800
dc.authorscopusid8633854100
dc.authorscopusid8955041400
dc.contributor.authorKarayildirim, Cinel Koksal
dc.contributor.authorGuner, Adem
dc.contributor.authorYigitturk, Gurkan
dc.contributor.authorInce, Iskender
dc.contributor.authorYasar, Mustafa
dc.contributor.authorYavasoglu, Nefise Ulku Karabay
dc.contributor.authorYavasoglu, Altug
dc.date.accessioned2024-08-25T18:32:16Z
dc.date.available2024-08-25T18:32:16Z
dc.date.issued2023
dc.departmentEge Üniversitesien_US
dc.description.abstractThis work was aimed at investigating the hepatoprotective effect of Hep-X, a polyherbal formulation containing Silybum marianum L. (Milk thistle), Rosmarinus officinalis L. (Rosemary), Curcuma longa L. (Turmeric) and Fumaria officinalis L. (Fumitory) as standardized botanical dietary supplement, on mice with CCl4-induced acute liver injury. The total phenolic and flavonoid contents of Hep-X were determined as 0.125 and 0.528 mg/mL, respectively. The quercetin content was determined as 50 mu g/mL using HPLC analysis. The total antioxidant capacity showed correlation between the Hep-X concentration and percentage inhibition of free radicals. Hep-X was administered orally at 25, 50 and 100 mg/kg b.w./day against CCl4-induced hepatotoxicity in mice. The hepatic damage was measured using blood biochemical parameters. Animals upon Hep-X treatment exhibited better drug effIcacy in certain blood parameters than silymarin-treated mice. Also, Hep-X administration significantly ameliorated the liver damage by suppressing iNOS expression and apoptosis as well as by recovery of the histological structure. The obtained results suggest that Hep-X is able to significantly alleviate the hepatotoxicity induced by CCl4 in mice, which can be due to antioxidant properties of the polyherbal formulation.en_US
dc.description.sponsorshipNaturin Nutraceuticals Products Company Izmir, Turkey; Ege University, Faculty of Science [2012/ILAM/002]en_US
dc.description.sponsorshipThis study was supported by the Naturin Nutraceuticals Products Company Izmir, Turkey and Ege University, Faculty of Science (Project Number 2012/ILAM/002)en_US
dc.identifier.doi10.1007/s11094-023-02839-8
dc.identifier.issn0091-150X
dc.identifier.issn1573-9031
dc.identifier.scopus2-s2.0-85150372380en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.urihttps://doi.org/10.1007/s11094-023-02839-8
dc.identifier.urihttps://hdl.handle.net/11454/100187
dc.identifier.wosWOS:000953858800002en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofPharmaceutical Chemistry Journalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmz20240825_Gen_US
dc.subjectCCl4-induced acute liver injuryen_US
dc.subjectHep-X polyherbal formulationen_US
dc.subjectbotanical dietary supplementen_US
dc.subjectprotective effecten_US
dc.subjecthistochemistryen_US
dc.subjectimmunohistochemistryen_US
dc.subjectCarbon-Tetrachlorideen_US
dc.subjectHepatic-Injuryen_US
dc.subjectSuppressionen_US
dc.subjectMechanismsen_US
dc.subjectRatsen_US
dc.titleTetrachloromethane Induced Acute Liver Injury in Mice: Biochemical and Histopathological Study of the Hepatoprotective Effect of Hep-X Standardized Botanical Dietary Supplementen_US
dc.typeArticleen_US

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