Synthesis, characterization and biological application of dinuclear Cu(II) complexes of Schiff base ligands of galactochloralose and ?-chloralose
Küçük Resim Yok
Tarih
2018
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Elsevier S.A.
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Four novel dinuclear Cu(II) complexes (1a–4a) have been prepared from ONO-tridentate chiral Schiff base derivatives of chloralose (1–4). All the new complexes (1a–4a) have been characterized by Fourier transform infrared spectroscopy, UV–visible spectroscopy and elemental analysis. The complex 2a was further characterized by X-Ray crystallography. And also, the magnetic susceptibility measurement of this complex (2a, µeff 2.61 BM/dimer) was measured at room temperature. The activities of ONO-tridentate chiral Schiff base derivatives of chloralose (1–4) and their dinuclear Cu(II) complexes (1a–4a) on viability of human cervical cancer cell line (HeLa) were investigated by MTT assay. The obtained results indicated that the Schiff base ligand 1 and its dinuclear Cu(II) complex (1a) have excellent cytotoxic activity. Also, dinuclear Cu(II) complexes of the galactochloralose and ?-chloralose derivative Schiff base ligands were screened for their in vitro antimicrobial activity against eight bacterial species as well as yeast species Candida albicans ATCC 10231 using disc diffusion method. Complex 4a exhibited promising in vitro antimicrobial activity with inhibition zone diameter from 10 to 22 mm against the tested Gram-positive bacterial strains and yeast C. albicans. © 2018 Elsevier B.V.
Açıklama
Anahtar Kelimeler
Anticancer activity, Antimicrobial activity, Chloralose, Dinuclear Cu(II) complex, ONO-tridentate chiral Schiff base
Kaynak
Inorganica Chimica Acta
WoS Q Değeri
Scopus Q Değeri
Q2
Cilt
483
