Electrospun thermoplastic polyurethane mats containing naproxen- cyclodextrin inclusion complex

Küçük Resim Yok

Tarih

2014

Dergi Başlığı

Dergi ISSN

Cilt Başlığı

Yayıncı

Technical University of Lodz

Erişim Hakkı

info:eu-repo/semantics/openAccess

Özet

Incorporation of cyclodextrins (CDs) into electrospun nanofibrous materials can be considered as potential candidates for functional medical textile applications. Naproxen (NAP) is a type of non-steroidal anti-inflammatory drug commonly administered for the treatment of pain, inflammation and fever. Drug-inclusion complex formation with CDs is an approach to improve the aqueous solubility via molecular encapsulation of the drug within the cavity of the more soluble CD molecule. In this study, NAP or different NAP-CD inclusion complexes loaded nanofibres were successfully produced through electrospinning and characterised. The inclusion complex loaded mats exhibited significantly faster release profiles than NAP-loaded thermoplastic polyurethane (TPU) mats. Overall, NAP-inclusion complex loaded TPU electrospun nanofibres could be used as drug delivery systems for acute pain treatments since they possess a highly porous structure that can release the drug immediately. © AUTEX.

Açıklama

Anahtar Kelimeler

2-hydroxy propyl-ß-CD, Drug release, Electrospinning, Inclusion complex, Naproxen, ß-cyclodextrin

Kaynak

Autex Research Journal

WoS Q Değeri

Scopus Q Değeri

Q3

Cilt

14

Sayı

4

Künye