Multifunctional molecular imaging probes for estrogen receptors: Tc-99m labeled diethylstilbestrol (DES) conjugated, cuinp quantum dot nanoparticles (DESCIP)

Basit Öğe Kaydı
dc.contributor.authorMoharrami, Payam
dc.contributor.authorUnak, Perihan
dc.contributor.authorGuldu, Ozge Kozgus
dc.contributor.authorMedine, E. I.
dc.contributor.authorGumuser, Gul
dc.contributor.authorBilgin, Elvan Sayit
dc.contributor.authorAras, Omer
dc.date.accessioned2019-10-27T10:47:41Z
dc.date.available2019-10-27T10:47:41Z
dc.date.issued2017
dc.departmentEge Üniversitesien_US
dc.description.abstractA theranostic nanoparticle was synthesized based on diethylstilbestrol conjugated with phosphate, copper, and indium (DESCIP) and labelled with Tc-99m which can be used for SPECT imaging of ER-enriched cancers. In vitro biological activity of Tc-99m-DESCIP was examined in breast adenocarcinoma cells (MCF-7), prostatic carcinoma cells (PC-3), and pulmonary epithelial cells (A-549). In vivo lymph node imaging was performed in normal and receptor blocked female New Zealand rabbits. Results demonstrated that Tc-99m-DESCIP and DESCIP has potential for imaging ER-enriched tumors such as breast and prostate tumors, and their metastases in the lung, as well as improving management for their therapies.en_US
dc.identifier.doi10.1007/s10967-017-5630-2
dc.identifier.endpage2620en_US
dc.identifier.issn0236-5731
dc.identifier.issn1588-2780
dc.identifier.issn0236-5731en_US
dc.identifier.issn1588-2780en_US
dc.identifier.issue3en_US
dc.identifier.startpage2609en_US
dc.identifier.urihttps://doi.org/10.1007/s10967-017-5630-2
dc.identifier.urihttps://hdl.handle.net/11454/31454
dc.identifier.volume314en_US
dc.identifier.wosWOS:000416545300117en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofJournal of Radioanalytical and Nuclear Chemistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectDiethylstilbestrolen_US
dc.subjectQuantum dot nanoparticlesen_US
dc.subjectCancer imagingen_US
dc.subjectBreast canceren_US
dc.subjectProstate canceren_US
dc.subjectLung canceren_US
dc.titleMultifunctional molecular imaging probes for estrogen receptors: Tc-99m labeled diethylstilbestrol (DES) conjugated, cuinp quantum dot nanoparticles (DESCIP)en_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu