In vitro evaluation of radiolabeled (125I) methanol extracts of yarrow in cell lines of MCF-7, PC-3, A-549 and Caco-2

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dc.contributor.authorYurt Kilcar A.
dc.contributor.authorCekic B.
dc.contributor.authorBiber Muftuler F.Z.
dc.contributor.authorUnak P.
dc.contributor.authorMedine E.I.
dc.date.accessioned2019-10-27T08:24:09Z
dc.date.available2019-10-27T08:24:09Z
dc.date.issued2013
dc.departmentEge Üniversitesien_US
dc.description.abstractNowadays, cancer is still the second leading cause of death all over the world. Therefore, natural products which have anticancer and antitumor properties are come into prominence. Achillea family is known with anticancer and antitumor activity. Yarrow which has over a hundred bioactive compounds is a member of Achillea family. In current study; components of yarrow which was obtained after methanol extraction and purification were radiolabeled with 125I and effects of these radiolabeled components on the cells were examined with using Caco-2, MCF-7, A-549, PC-3 cell lines. As a result of these studies, seven peaks were obtained and the highest radiolabeling yield was calculated for 125I radiolabeled Peak 7 (95.00 ± 7.07, n = 4). To screen the biological properties of these radiolabeled peaks at determined cell lines, our ongoing effort was to evaluate incorporation percentage with time dependent. Furthermore, 125I-Peak 7 had highest incorporation ratio for whole cell lines and its incorporation percentage was increased with time dependent. Results of these in vitro studies were compatible with previous in vivo studies and traditional use of yarrow plants. © 2012 Akadémiai Kiadó, Budapest, Hungary.en_US
dc.identifier.doi10.1007/s10967-012-1895-7
dc.identifier.endpage599en_US
dc.identifier.issn0236-5731
dc.identifier.issn0236-5731en_US
dc.identifier.issue1en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage593en_US
dc.identifier.urihttps://doi.org/10.1007/s10967-012-1895-7
dc.identifier.urihttps://hdl.handle.net/11454/26538
dc.identifier.volume295en_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.relation.ispartofJournal of Radioanalytical and Nuclear Chemistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCell culture (MCF-7, PC-3, A-549, Caco-2 cell lines)en_US
dc.subjectMethanol extraction of yarrowen_US
dc.subjectRadiolabeled with 125Ien_US
dc.titleIn vitro evaluation of radiolabeled (125I) methanol extracts of yarrow in cell lines of MCF-7, PC-3, A-549 and Caco-2en_US
dc.typeArticleen_US

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