Synthesis, characterization and biological application of dinuclear Cu(II) complexes of Schiff base ligands of galactochloralose and alpha-chloralose

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dc.contributor.authorSalman, Yesim
dc.contributor.authorBarlas, Firat Baris
dc.contributor.authorYavuz, Murat
dc.contributor.authorKaya, Kerem
dc.contributor.authorTimur, Suna
dc.contributor.authorTelli, Fatma Cetin
dc.date.accessioned2019-10-27T10:01:16Z
dc.date.available2019-10-27T10:01:16Z
dc.date.issued2018
dc.departmentEge Üniversitesien_US
dc.description.abstractFour novel dinuclear Cu(II) complexes (1a-4a) have been prepared from ONO-tridentate chiral Schiff base derivatives of chloralose (1-4). All the new complexes (1a-4a) have been characterized by Fourier transform infrared spectroscopy, UV-visible spectroscopy and elemental analysis. The complex 2a was further characterized by X-Ray crystallography. And also, the magnetic susceptibility measurement of this complex (2a, mu(eff) 2.61 BM/dimer) was measured at room temperature. The activities of ONO-tridentate chiral Schiff base derivatives of chloralose (1-4) and their dinuclear Cu(II) complexes (1a-4a) on viability of human cervical cancer cell line (HeLa) were investigated by MIT assay. The obtained results indicated that the Schiff base ligand 1 and its dinuclear Cu(II) complex (1a) have excellent cytotoxic activity. Also, dinuclear Cu(II) complexes of the galactochloralose and alpha-chloralose derivative Schiff base ligands were screened for their in vitro antimicrobial activity against eight bacterial species as well as yeast species Candida albicans ATCC 10231 using disc diffusion method. Complex 4a exhibited promising in vitro antimicrobial activity with inhibition zone diameter from 10 to 22 mm against the tested Gram-positive bacterial strains and yeast C. albicans.en_US
dc.description.sponsorshipEge UniversityEge University [2014 FEN 071]en_US
dc.description.sponsorshipWe would like to Ege University for financial support of this work (2014 FEN 071) and Associate Prof. Dr. Serpil Denizalti for carrying out the magnetic susceptibility measurement.en_US
dc.identifier.doi10.1016/j.ica.2018.08.010
dc.identifier.endpage105en_US
dc.identifier.issn0020-1693
dc.identifier.issn1873-3255
dc.identifier.issn0020-1693en_US
dc.identifier.issn1873-3255en_US
dc.identifier.startpage98en_US
dc.identifier.urihttps://doi.org/10.1016/j.ica.2018.08.010
dc.identifier.urihttps://hdl.handle.net/11454/29819
dc.identifier.volume483en_US
dc.identifier.wosWOS:000445543100014en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.language.isoenen_US
dc.publisherElsevier Science Saen_US
dc.relation.ispartofInorganica Chimica Actaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectDinuclear Cu(II) complexen_US
dc.subjectONO-tridentate chiral Schiff baseen_US
dc.subjectChloraloseen_US
dc.subjectAnticancer activityen_US
dc.subjectAntimicrobial activityen_US
dc.titleSynthesis, characterization and biological application of dinuclear Cu(II) complexes of Schiff base ligands of galactochloralose and alpha-chloraloseen_US
dc.typeArticleen_US

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