Semen Cannabis and Oleum Hyperici: Antileishmanial activity against Leishmania tropica promastigotes and intracellular amastigotes

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dc.contributor.authorYıldırım A.
dc.contributor.authorAksoy T.
dc.contributor.authorKayalar H.
dc.contributor.authorBalcıoğlu İ.C.
dc.date.accessioned2024-08-31T07:42:29Z
dc.date.available2024-08-31T07:42:29Z
dc.date.issued2024
dc.departmentEge Üniversitesien_US
dc.description.abstractThe exploration of alternative agents and novel drug candidates for the effective treatment of cutaneous leishmaniasis has garnered significant attention, driven by the high cost, toxic effects, and the emergence of drug resistance associated with current therapeutic options. Plant extracts derived from Semen Cannabis, the seeds of the Cannabis sativa L. (hemp) plant, and Oleum Hyperici, the oily macerate of Hypericum perforatum L. (St. John's Wort) plant, were prepared by using solvents of varying polarity (n-hexane, chloroform, ethanol, and 60% aqueous ethanol). The primary objective of this study was to research in vitro and ex vivo antileishmanial efficacy of Semen Cannabis and Oleum Hyperici plant extracts against Leishmania tropica promastigotes and intracellular amastigotes. The efficacy of plant extracts against promastigotes were assessed using the cell counting by hemocytometer and the CellTiter-Glo assay. Additionally, their impact on infected THP-1 macrophages and the quantity of intracelluler amastigotes were investigated. Cytotoxicity was evaluated in THP-1 macrophages. Among the tested plant extracts, chloroform extract of Oleum Hyperici demonstrated significant antileishmanial activity against promastigotes (SI: 12.6) and intracellular amastigotes (SI: 16.8) of L. tropica without inducing cytotoxic effects and hold promise for further investigation as potential antileishmanial agents. © 2024 Elsevier B.V.en_US
dc.identifier.doi10.1016/j.parint.2024.102950
dc.identifier.issn1383-5769
dc.identifier.scopus2-s2.0-85201293826en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://doi.org10.1016/j.parint.2024.102950
dc.identifier.urihttps://hdl.handle.net/11454/103900
dc.identifier.volume103en_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherElsevier Ireland Ltden_US
dc.relation.ispartofParasitology Internationalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmz20240831_Uen_US
dc.subjectAntileishmanial activityen_US
dc.subjectCutaneous leishmaniasisen_US
dc.subjectLeishmania tropicaen_US
dc.subjectOleum Hypericien_US
dc.subjectSemen Cannabisen_US
dc.titleSemen Cannabis and Oleum Hyperici: Antileishmanial activity against Leishmania tropica promastigotes and intracellular amastigotesen_US
dc.typeArticleen_US

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