Hyaluronic acid-based nanosystems for theranostic delivery and imaging

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dc.authorscopusid57193741014
dc.authorscopusid56662137100
dc.authorscopusid57221835140
dc.authorscopusid35774636300
dc.contributor.authorKarpuz, M.
dc.contributor.authorOzgenc, E.
dc.contributor.authorAtlihan-Gundogdu, E.
dc.contributor.authorSenyigit, Z.
dc.date.accessioned2024-08-25T18:53:40Z
dc.date.available2024-08-25T18:53:40Z
dc.date.issued2023
dc.departmentEge Üniversitesien_US
dc.description.abstractIn recent years, novel approaches including targeted drug delivery systems have attracted to correctly diagnose diseases at the early stages, minimize side effects of drugs, and obtaining better treatment responses. Hyaluronic acid (HA), a natural glycosaminoglycan, is widely used in pharmaceutical, biomedical, and cosmetic applications due to its biocompatible, biodegradable, nontoxic, nonimmunogenic, and chemically modifiable properties. Furthermore, HA can be used as a hydrophilic polymer or an active targeting ligand in the formulation of nanosized systems or drug conjugates. The use of HA as a hydrophilic polymer increases the drug solubility and bioavailability, and it provides to escape from opsonization by macrophages in blood circulation. HA also plays a critical role in the targeting of drugs or nanosystems to cancer cells that overexpress CD44, LYVE-1, and HMM receptors. Therefore, various studies regarding HA-based nanosized systems and drug conjugates have been studied to develop more effective imaging and/or therapeutic agents. This chapter aims to summarize the properties of HA, review the role of HA in drug conjugates, and explain the importance and advantages of HA in future aspects including nanosized drug delivery systems and theranostic approach for imaging and/or therapy. © 2023 Elsevier Inc. All rights reserved.en_US
dc.identifier.doi10.1016/B978-0-323-85656-0.00013-9
dc.identifier.endpage308en_US
dc.identifier.isbn9780323856560
dc.identifier.isbn9780323885775
dc.identifier.scopus2-s2.0-85160115533en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage271en_US
dc.identifier.urihttps://doi.org/10.1016/B978-0-323-85656-0.00013-9
dc.identifier.urihttps://hdl.handle.net/11454/103198
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.relation.ispartofPolymeric Nanosystems: Theranostic Nanosystems: Volume 1en_US
dc.relation.publicationcategoryKitap Bölümü - Uluslararasıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmz20240825_Gen_US
dc.subjectcisplatinen_US
dc.subjectcurcuminen_US
dc.subjectDrug deliveryen_US
dc.subjecthyaluronic aciden_US
dc.subjectnanoparticlesen_US
dc.titleHyaluronic acid-based nanosystems for theranostic delivery and imagingen_US
dc.typeBook Chapteren_US

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