Radiotherapy can be a Cofactor in the Development and Severity of Lapatinib-Capecitabine-Related Skin Rash

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dc.contributor.authorDuman, Nilay
dc.contributor.authorDemir, Meryem
dc.contributor.authorOn, Sercan
dc.contributor.authorOzsaran, Zeynep
dc.date.accessioned2024-08-25T18:45:38Z
dc.date.available2024-08-25T18:45:38Z
dc.date.issued2023
dc.departmentEge Üniversitesien_US
dc.description.abstractSkin rash induced by concurrent radiotherapy during lapatinib-capecitabine (LC) treatment has been rarely reported. We aim to draw attention to the potential of radiotherapy to act as a cofactor in the development of LC-related skin rash.Herein, we report a case with a drug-related skin rash triggered by radiotherapy during LC treatment.A 31-year-old woman with inflammatory metastatic breast cancer presented with a skin rash during LC treatment combined with radiotherapy. She was started on LC treatment, and palliative whole cranial radiotherapy was applied 3 days later. Three days after the radiotherapy, acneiform lesions started from the scalp and a maculopapular rash developed on the trunk and extremities. LC treatment was interrupted and skin lesions regressed rapidly with topical dermatological care, oral H1-antihistamine, and short-term oral steroid treatment. Although LC treatment was restarted alone in the follow-up, no recurrence was observed.Radiotherapy may be a cofactor in the development and severity of skin toxicity during LC treatment. There is a need to elucidate whether the immunological mechanisms of skin eruptions occurring during concomitant chemoradiotherapy are due to the radiosensitizing effects of biological agents or exacerbation by radiotherapy.en_US
dc.identifier.doi10.21911/aai.247
dc.identifier.issn1308-9234
dc.identifier.urihttps://doi.org/10.21911/aai.247
dc.identifier.urihttps://hdl.handle.net/11454/101623
dc.identifier.wosWOS:001020135900001en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.language.isoenen_US
dc.publisherBilimsel Tip Yayinevien_US
dc.relation.ispartofAstim Allerji Immunolojien_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmz20240825_Gen_US
dc.subjectLapatiniben_US
dc.subjectcapecitabineen_US
dc.subjectradiotherapyen_US
dc.subjectskin rashen_US
dc.subjectdrug allergyen_US
dc.subjectManagementen_US
dc.subjectToxicityen_US
dc.titleRadiotherapy can be a Cofactor in the Development and Severity of Lapatinib-Capecitabine-Related Skin Rashen_US
dc.typeArticleen_US

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