Multiple Mechanisms Synergistically Induce Pseudomonas Aeruginosa Multiple Drug Resistance

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dc.authorscopusid57219814022
dc.authorscopusid57190168671
dc.authorscopusid57226752675
dc.authorscopusid57215715808
dc.authorscopusid57216655940
dc.authorscopusid7404975498
dc.authorscopusid7402140064
dc.contributor.authorDai, Pei
dc.contributor.authorJiao, Fangyan
dc.contributor.authorYang, Lulu
dc.contributor.authorBajinka, Ousman
dc.contributor.authorAbdelhalim, Khalid A.
dc.contributor.authorWu, Guojun
dc.contributor.authorTan, Yurong
dc.date.accessioned2024-08-25T18:53:36Z
dc.date.available2024-08-25T18:53:36Z
dc.date.issued2023
dc.departmentEge Üniversitesien_US
dc.description.abstractThe aim of this study was to understand the molecular epidemiological characteristics and drug resistance mechanism of carbapenem-resistant Pseudomonas aeruginosa (CRPA) and to provide a theoretical basis for the prevention and treatment of CRPA infection in hospitals. A total of 34 CRPA strains were isolated, and resistance to 13 commonly used antibiotics was detected using the TDR-300B Plus VitEK-2 compact automatic bacterial identification instrument. Then, carbapenemase production was detected using the Carbe NP test. RT-qPCR was used to detect the expression of efflux pump MexA and outer membrane protein OprD, and PCR amplification and sequence analysis were used to detect class I integrons carried by drug resistance genes. Our results showed that of the 34 CRPAs, 22 were multi-drug resistant (MDR), and five were extensively drug-resistant (XDR). Sequencing analysis showed that class I integron mainly carried aminoglycosides or quinolones resistance genes. Multiple mechanisms play important roles in the formation and development of MDR or XDR.en_US
dc.description.sponsorshipNational Natural Science Foundation of China [31771277]en_US
dc.description.sponsorshipThis work was supported by Grant 31771277 from the National Natural Science Foundation of China.en_US
dc.identifier.doi10.3390/microbiolres14020044
dc.identifier.endpage634en_US
dc.identifier.issn2036-7481
dc.identifier.issue2en_US
dc.identifier.scopus2-s2.0-85163730354en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage627en_US
dc.identifier.urihttps://doi.org/10.3390/microbiolres14020044
dc.identifier.urihttps://hdl.handle.net/11454/103178
dc.identifier.volume14en_US
dc.identifier.wosWOS:001014595900001en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherMDPIen_US
dc.relation.ispartofMicrobiology Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmz20240825_Gen_US
dc.subjectPseudomonas aeruginosaen_US
dc.subjectcarbapenemen_US
dc.subjectdrug resistance mechanismsen_US
dc.subjectMDRen_US
dc.subjectXDRen_US
dc.subjectPumpen_US
dc.titleMultiple Mechanisms Synergistically Induce Pseudomonas Aeruginosa Multiple Drug Resistanceen_US
dc.typeArticleen_US

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