Design of Tc-99(m) radiolabeled gemcitabine polymeric nanoparticles as drug delivery system and in vivo evaluation

Basit Öğe Kaydı
dc.contributor.authorIchedef, Cigdem
dc.contributor.authorTeksoz, Serap
dc.contributor.authorCetin, Oguz
dc.contributor.authorAydin, Burcu
dc.contributor.authorSarikavak, Ibrahim
dc.contributor.authorParlak, Yasemin
dc.contributor.authorBilgin, Bedriye Elvan
dc.date.accessioned2021-05-03T20:21:27Z
dc.date.available2021-05-03T20:21:27Z
dc.date.issued2021
dc.departmentEge Üniversitesien_US
dc.description.abstractThe main objective of this study is to create a multifunctional drug carrier system as a prototype product. For this purpose, Gemcitabine that used as an anticancer agent for several kinds of tumour therapy, and technetium(I)-tricarbonyl core, [Tc-99m(CO)(3)](+), was incorporated to the polymeric structure. in the current study PLA-PEG-COOH (polylactic acid-polyethylene glycol-carboxyl) copolymer was synthesized and the structure analysis was performed by FT-IR and H-1 NMR. The surface charge, size and morphology of the polymeric nanoparticles was evaluated by Zeta Potential (ZP) analysis, Dynamic Light Scattering (DLS) and Scanning Electron Microscopy (SEM) methods. Gemcitabine loaded polymeric nanoparticles were radiolabeled with [Tc-99m(CO)(3)(H2O)(3)](+) and quality controls were performed by thin layer radiochromatograpy (TLRC) and high performance liquid radiochmmatograpy (HPLRC). PLA-PEG-GEM complex was labeled with [Tc-99m(CO)(3)](+) in high radiochemical yield and purity. The radiolabeled complex is stable during the study period in saline solution. The biological activity of this radiolabeled system was evaluated performing biodistribution and gamma camera imaging on Wistar Albino rats which exhibited higher uptake in the lung and liver at all selected time points.en_US
dc.description.sponsorshipManisa Celal Bayar University Scientific Research Projects Coordination UnitCelal Bayar University [2017001]en_US
dc.description.sponsorshipName of funding agency: Manisa Celal Bayar University Scientific Research Projects Coordination Unit. Grant Number: 2017001.en_US
dc.identifier.doi10.1016/j.matchemphys.2021.124380
dc.identifier.issn0254-0584
dc.identifier.issn1879-3312
dc.identifier.issn0254-0584en_US
dc.identifier.issn1879-3312en_US
dc.identifier.scopus2-s2.0-85101386494en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://doi.org/10.1016/j.matchemphys.2021.124380
dc.identifier.urihttps://hdl.handle.net/11454/69324
dc.identifier.volume263en_US
dc.identifier.wosWOS:000632971800002en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherElsevier Science Saen_US
dc.relation.ispartofMaterials Chemistry and Physicsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCytotoxic drugen_US
dc.subjectRadiolabelingen_US
dc.subjectDrug delivery systemen_US
dc.subjectBiodistributionen_US
dc.subjectImagingen_US
dc.titleDesign of Tc-99(m) radiolabeled gemcitabine polymeric nanoparticles as drug delivery system and in vivo evaluationen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu