Is there an association between migraine and atopic disorders? The results of multicenter migraine attack study

Basit Öğe Kaydı
dc.contributor.authorOzge, Aynur
dc.contributor.authorOzturk, Candan
dc.contributor.authorDora, Babuer
dc.contributor.authorInan, Levent
dc.contributor.authorSaip, Sebahattin
dc.contributor.authorOzturk, Musa
dc.contributor.authorVanli, Ebru Nur
dc.contributor.authorGokcay, Figen
dc.contributor.authorOzturk, Vesile
dc.contributor.authorErdemoglu, Ali Kemal
dc.contributor.authorTasmertek, Fazilet
dc.contributor.authorYilmaz, Nurguel
dc.contributor.authorOzer, Gokhan
dc.contributor.authorSiva, Aksel
dc.contributor.authorDemir, Nurhak
dc.contributor.authorBaykan, Betuel
dc.contributor.authorGuler, Ayse
dc.contributor.authorPoyraz, Turan
dc.contributor.authorDoner, Hatice
dc.contributor.authorSirin, Hadiye
dc.date.accessioned2019-10-27T19:57:14Z
dc.date.available2019-10-27T19:57:14Z
dc.date.issued2008
dc.departmentEge Üniversitesien_US
dc.description.abstractWe designed this multicenter study to evaluate the abnormalities related to the mast cell activation during attacks in a large group of migraineurs and to compare the findings both with episodic tension type headache (ETTH) and matched healthy control subjects. After the evaluation of diagnostic criteria, 213 subjects were included in this study after giving consent. Of all 146 subjects (67.8%) were migraineurs, 38 (19.4%) were ETTH patients and 29 others were healthy controls matched according to age and sex. Immunological screening showed significantly high ratios of IL-beta, IL-2, IL-6 and TNF-alpha in the migraine group compared to ETTH (16.6% vs 10.5%, 20.0% vs 5.3%, 13.8% vs 2.6% and 15.9% vs 5.3%, respectively) and to the healthy controls. Logistic regression analysis showed that only duration of headache has an important effect on having IL-2 abnormality (Exp-B: 0.322, 95% CI: 0.151-0.688, p=0.003) in patients with migraine. There was no important effect of clinical variables on serological abnormalitites or each other. In conclusion, our multicenter clinical and laboratory based study suggests that primary headache disorders (migraine and ETTH) are associated with atopic changes and they might share the inflammatory mechanism (pro-inflammatory as well as anti-inflammatory cytokine abnormalities) during headache attacks.en_US
dc.identifier.endpageU5en_US
dc.identifier.issn1302-1664
dc.identifier.issn1302-1664en_US
dc.identifier.issue3en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage136en_US
dc.identifier.urihttps://hdl.handle.net/11454/40925
dc.identifier.volume25en_US
dc.identifier.wosWOS:000259840600001en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherJournal Neurological Sciencesen_US
dc.relation.ispartofJournal of Neurological Sciences-Turkishen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectmigraineen_US
dc.subjecttension type headacheen_US
dc.subjectcytokineen_US
dc.subjectimmunologicen_US
dc.subjectpro-inflammatoryen_US
dc.subjectanti-inflammatoryen_US
dc.titleIs there an association between migraine and atopic disorders? The results of multicenter migraine attack studyen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu