The Potential Hepatoprotective and Antioxidant Activities of Astragalus davisii against Paracetamol Induced Liver Damage in Rats

Basit Öğe Kaydı
dc.contributor.authorFoudah, Ahmed, I
dc.contributor.authorAlqarni, Mohammed H.
dc.contributor.authorSoliman, Gamal A.
dc.contributor.authorAbdel-Rahman, Rehab F.
dc.contributor.authorAlankus-Caliskan, Ozgen
dc.contributor.authorGanaie, Majid A.
dc.contributor.authorYusufoglu, Hasan
dc.date.accessioned2020-12-01T12:05:05Z
dc.date.available2020-12-01T12:05:05Z
dc.date.issued2020
dc.departmentEge Üniversitesien_US
dc.description.abstractThe current study aimed to estimate in vitro antioxidant effect of Astragalus davisii (A. davisii) extract. Further, the possible protective effect of A. davisii against paracetamol (PCM)-induced liver injury was assessed in rats. A. davisii was tested for its antioxidant activity using DPPH radical scavenging assay. the hepatoprotective potential of the extract was assessed in rats following oral administration for 7 days. Liver injury was induced in rats following oral administration of PCM overdose. Hepatic biomarkers; alanine-aminotransferase, aspartate-aminotransferase, alkaline-phosphatase, gamma-glutamyl transferase and bilirubin were increased, while total protein and albumin were reduced in PCM control animals. Additionally, the activities of superoxide dismutase (SOD), catalase and glutathione-peroxidase (GPx) and the levels of glutathione were significantly declined, while levels of hepatic malondialdehyde (MDA) were significantly elevated in PCM alone treated rats. Oral administration of A. davisii (400 mg/kg) prior to PCM inhibited the elevation in the levels of liver damage markers in serum and protected against oxidative stress. Histopathological remarks confirmed the hepatoprotective potential of the extract. the results suggest that A. davisii extract at 400 mg/kg protects liver against injury induced by PCM overdose.en_US
dc.description.sponsorshipDeanship of Scientific Research at Prince Sattam bin Abdulaziz University, Al-kharj, Saudi Arabiaen_US
dc.description.sponsorshipThis publication was supported by the Deanship of Scientific Research at Prince Sattam bin Abdulaziz University, Al-kharj, Saudi Arabia.en_US
dc.identifier.doi10.9734/JPRI/2020/v32i2330797
dc.identifier.endpage114en_US
dc.identifier.issn2456-9119
dc.identifier.issn2456-9119en_US
dc.identifier.issue23en_US
dc.identifier.startpage102en_US
dc.identifier.urihttps://doi.org/10.9734/JPRI/2020/v32i2330797
dc.identifier.urihttps://hdl.handle.net/11454/62873
dc.identifier.volume32en_US
dc.identifier.wosWOS:000575225700011en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.language.isoenen_US
dc.publisherSciencedomain Inten_US
dc.relation.ispartofJournal of Pharmaceutical Research Internationalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectHepatotoxicityen_US
dc.subjectleguminosaeen_US
dc.subjectDPPHen_US
dc.subjectliver markersen_US
dc.titleThe Potential Hepatoprotective and Antioxidant Activities of Astragalus davisii against Paracetamol Induced Liver Damage in Ratsen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu