Antimicrobial Resistance Rates and Risk Factors for Extended-Spectrum Beta-Lactamase-Producing Escherichia coli-Associated Urinary Tract Infections in Older Outpatients in East Anatolia from 2011-2019

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dc.authorscopusid36572380900
dc.authorscopusid55671858800
dc.authorscopusid56455335500
dc.contributor.authorSahin, Sevnaz
dc.contributor.authorKarasahin, Omer
dc.contributor.authorTasar, Pinar Tosun
dc.date.accessioned2024-08-25T18:48:09Z
dc.date.available2024-08-25T18:48:09Z
dc.date.issued2023
dc.departmentEge Üniversitesien_US
dc.description.abstractBackground: Community-acquired urinary tract infection is among the most common infections in older adults. Regardless of age, the most frequently detected causative microorganism is Escherichia coli. In parallel with the increase in antibiotic use, the frequency of community-acquired extended-spectrum beta-lactamase-producing E. coli (ESBL-E. coli) has reached critical levels. The use of empirical antibiotic therapy is determined by assessing patient-based risk factors. Therefore, knowing the risk factors and the frequency of antimicrobial resistance can guide the treatment to shape the treatment.Objectives: This study aimed to determine the risks and resistance frequencies to guide the empirical treatment selection for ESBL-E. coli-associated urinary tract infection (UTI) in elderly patients.Methods: This study is a retrospective cohort study. It was carried out between 2011-2019. Escherichia coli growth of >= 105 colony -forming units (cfu)/mL in urine culture was included in 815 patients aged 65 and over who applied to outpatient clinics.Results: Two hundred and sixty (31.9%) of the patients had ESBL-E. coli. In ESBL-E. coli, antimicrobial resistance rates were highest (100%) for penicillins + beta-lactamase inhibitors. The lowest resistance rates were determined for carbapenems, aminoglycosides, phosphonic acid, and nitrofurantoins. Risk factors for ESBL-producing bacteria were determined. These were the presence of benign prostatic hypertrophy, antibiotic use in the last three months, history of UTI in the last year, urinary catheter uses in the last year, male gender, and hospitalization in the last year (P < 0.05). The only independent risk factor was a history of UTI in the last year, which increased the risk of ESBL by 2.8 times.Conclusions: Carbapenems can be chosen as parenteral options, and phosphonic acids and nitrofurantoin as oral options for em-pirical antibiotic treatment, especially in patients with a history of UTI in the past year.en_US
dc.identifier.doi10.5812/jjm-132890
dc.identifier.issn2008-3645
dc.identifier.issn2008-4161
dc.identifier.issue2en_US
dc.identifier.scopus2-s2.0-85160341592en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.urihttps://doi.org/10.5812/jjm-132890
dc.identifier.urihttps://hdl.handle.net/11454/102171
dc.identifier.volume16en_US
dc.identifier.wosWOS:001008707700001en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherBrieflanden_US
dc.relation.ispartofJundishapur Journal of Microbiologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmz20240825_Gen_US
dc.subjectUrinary Tract Infectionsen_US
dc.subjectAntimicrobial Resistanceen_US
dc.subjectElderlyen_US
dc.subjectTurkeyen_US
dc.subjectSusceptibilityen_US
dc.subjectEpidemiologyen_US
dc.subjectBacteriaen_US
dc.subjectPatternsen_US
dc.titleAntimicrobial Resistance Rates and Risk Factors for Extended-Spectrum Beta-Lactamase-Producing Escherichia coli-Associated Urinary Tract Infections in Older Outpatients in East Anatolia from 2011-2019en_US
dc.typeArticleen_US

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