Efficacy of IKVAV Peptide on HUVEC Microtissue Growth [HUVEC Mikrodokusu Büyümesi Üzerinde IKVAV Peptidinin Etkisi]

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dc.contributor.authorKöken B.
dc.contributor.authorYarali Z.B.
dc.contributor.authorKaraman O.
dc.date.accessioned2019-10-26T21:14:10Z
dc.date.available2019-10-26T21:14:10Z
dc.date.issued2018
dc.departmentEge Üniversitesien_US
dc.description2018 Medical Technologies National Congress, TIPTEKNO 2018 -- 8 November 2018 through 10 November 2018 -- 144203en_US
dc.description.abstractThe extracellular matrix (ECM) structure of the three-dimensional (3D) network of cells in body play an important role in cellular events. Cell-cell and cell-matrix interactions can be achieved in 3D cell culture systems as in vivo systems. For this reason, the loss of cell functions is less in 3D cultures than in two dimensional systems. Human umbilical cord vein endothelial cells (HUVECs) which are model cell types, are frequently used because of easily isolation and using vasculogenesis research in 3D culture. The isoleucine-Iysine-valine-alanine-valine (Ile-Lys- Val-Ala-Val (IKVAV)) sequence, one of the most effective units of laminin, is used as a support material in the ECM. IKVAV peptides can affect many cellular functions such as adhesion, proliferation, migration, metastasis, and are used in cell culture systems. The effects of IKVAV peptide on HUVEC microtissues were examined in this study. Increase in diameter was observed in microtissues incubated with concentrations of 0.5 and 1 mM peptides. Also when comparison of microtissues with and without peptide concentrations, has been shown to the IKVAV peptide increase cell viability. Compared with 0.5 and 1 mM, higher cell viability and diameter values are observed at 1 mM peptide concentration. This information supports the results of monolayer studies in the literature. © 2018 IEEE.en_US
dc.identifier.doi10.1109/TIPTEKNO.2018.8597062
dc.identifier.isbn9781538668528
dc.identifier.scopusqualityN/Aen_US
dc.identifier.urihttps://doi.org/10.1109/TIPTEKNO.2018.8597062
dc.identifier.urihttps://hdl.handle.net/11454/15844
dc.indekslendigikaynakScopusen_US
dc.language.isotren_US
dc.publisherInstitute of Electrical and Electronics Engineers Inc.en_US
dc.relation.ispartof2018 Medical Technologies National Congress, TIPTEKNO 2018en_US
dc.relation.publicationcategoryKonferans Öğesi - Uluslararası - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectHUVEC cell lineen_US
dc.subjectIKVAV peptideen_US
dc.subjectmicrotissueen_US
dc.titleEfficacy of IKVAV Peptide on HUVEC Microtissue Growth [HUVEC Mikrodokusu Büyümesi Üzerinde IKVAV Peptidinin Etkisi]en_US
dc.typeConference Objecten_US

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