Effect of octreotide on oxidative stress in the erythrocyte and kidney tissue in adriamycin-induced experimental nephrotic syndrome model; [Efeito do octreotide no estresse oxidativo em eritrócitos e no tecido renal no modelo de síndrome nefrótica experimental induzida por adriamicina]

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dc.contributor.authorCavdar S.
dc.contributor.authorAcar A.G.
dc.contributor.authorCamyar A.
dc.contributor.authorHür E.
dc.contributor.authorSozmen E.
dc.contributor.authorSen S.
dc.contributor.authorOzısık M.
dc.date.accessioned2024-08-31T07:42:40Z
dc.date.available2024-08-31T07:42:40Z
dc.date.issued2024
dc.departmentEge Üniversitesien_US
dc.description.abstractIntroduction: Nephrotic syndrome (NS) is one of the reasons of end-stage kidney disease, and elucidating the pathogenesis and offer new treatment options is important. Oxidative stress might trigger pathogenesis systemically or isolated in the kidneys. Octreotide (OCT) has beneficial antioxidant effects. We aimed to investigate the source of oxidative stress and the effect of OCT on experimental NS model. Methods: Twenty-four non-uremic Wistar albino rats were divided into 3 groups. Control group, 2 mL saline intramuscular (im); NS group, adriamycin 5 mg/kg intravenous (iv); NS treatment group, adriamycin 5 mg/kg (iv) and OCT 200 mcg/kg (im) were administered at baseline (Day 0). At the end of 21 days, creatinine and protein levels were measured in 24-hour urine samples. Erythrocyte and renal catalase (CAT) and thiobarbituric acid reactive substance (TBARS) were measured. Renal histology was also evaluated. Results: There was no significant difference among the 3 groups in terms of CAT and TBARS in erythrocytes. Renal CAT level was lowest in NS group, and significantly lower than the control group. In treatment group, CAT level significantly increased compared with NS group. In terms of renal histology, tubular and interstitial evaluations were similar in all groups. Glomerular score was significantly higher in NS group compared with control group and it was significantly decreased in treatment group compared to NS group. Conclusions: Oxidative stress in NS might be due to the decrease in antioxidant protection mechanism in kidney. Octreotide improves antioxidant levels and histology in renal tissue and might be a treatment option. © 2024 Sociedade Brasileira de Nefrologia. All rights reserved.en_US
dc.description.sponsorshipFundo de Pesquisa e Apoio a Projetos da Ege University, (2011-TIP-060)en_US
dc.identifier.doi10.1590/2175-8239-JBN-2022-0180pt
dc.identifier.endpage29en_US
dc.identifier.issn0101-2800
dc.identifier.issue1en_US
dc.identifier.scopus2-s2.0-85191367107en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage19en_US
dc.identifier.urihttps://doi.org/10.1590/2175-8239-JBN-2022-0180pt
dc.identifier.urihttps://hdl.handle.net/11454/103957
dc.identifier.volume46en_US
dc.indekslendigikaynakScopusen_US
dc.language.isopten_US
dc.publisherSociedade Brasileira de Nefrologiaen_US
dc.relation.ispartofBrazilian Journal of Nephrologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmz20240831_Uen_US
dc.subjectCatalaseen_US
dc.subjectNephrotic Syndromeen_US
dc.subjectOctreotideen_US
dc.subjectOxidative Stressen_US
dc.subjectReactive Oxygen Speciesen_US
dc.subjectThiobarbituric Acid Reactive Substanceen_US
dc.titleEffect of octreotide on oxidative stress in the erythrocyte and kidney tissue in adriamycin-induced experimental nephrotic syndrome model; [Efeito do octreotide no estresse oxidativo em eritrócitos e no tecido renal no modelo de síndrome nefrótica experimental induzida por adriamicina]en_US
dc.typeArticleen_US

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