Bioavailability of Tc-99m-paclitaxel-glucuronide (Tc-99m-PAC-G)

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dc.contributor.authorMuftuler, F. Z. Biber
dc.contributor.authorDemir, I.
dc.contributor.authorUnak, P.
dc.contributor.authorIchedef, C.
dc.contributor.authorKilcar, A. Yurt
dc.date.accessioned2019-10-27T21:28:01Z
dc.date.available2019-10-27T21:28:01Z
dc.date.issued2011
dc.departmentEge Üniversitesien_US
dc.description.abstractAn antitumor agent paclitaxel (PAC) has been proved to be efficient in the treatment of breast and ovarian cancer. Glucuronic acid-derived paclitaxel compound (paclitaxel-glucuronide (PAC-G)) was enzymatically synthesized using microsome preparate separated from rat livers. The biodistribution mechanism of PAC-G in healthy female Albino Wistar rats has been investigated. The expected structure is confirmed according to LC/MS results, and the possible attachment is to C2-hydroxyl group. PAC-G was labeled with Tc-99m and the radiochemical yield of radiolabeled compound (Tc-99m-PAC-G) was 98.00 +/- 2.74% (n = 9). The range of the breast/blood and breast/muscle ratios is approximately between 3 and 35 in 240 min. All these experimental studies indicate that Tc-99m-PAC-G may potentially be used in breast tissue as an imaging agent.en_US
dc.description.sponsorshipT.R. Prime Ministry State Planning Organization [06 DPT 06]; Ege UniversityEge University [2008 NBE 008]en_US
dc.description.sponsorshipWe thank MS student Hasan ZORA and Eser UCAR for technical help. This work was supported by T.R. Prime Ministry State Planning Organization (contract no 06 DPT 06) and Ege University Research Fund (contract no 2008 NBE 008).en_US
dc.identifier.doi10.1524/ract.2011.1827
dc.identifier.endpage306en_US
dc.identifier.issn0033-8230
dc.identifier.issn0033-8230en_US
dc.identifier.issue5en_US
dc.identifier.startpage301en_US
dc.identifier.urihttps://doi.org/10.1524/ract.2011.1827
dc.identifier.urihttps://hdl.handle.net/11454/45146
dc.identifier.volume99en_US
dc.identifier.wosWOS:000290916400007en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.language.isoenen_US
dc.publisherWalter De Gruyter Gmbhen_US
dc.relation.ispartofRadiochimica Actaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectPaclitaxel (PAC)en_US
dc.subjectPaclitaxel-glucuronideen_US
dc.subjectTc-99m paclitaxel-glucuronide (Tc-99m-PAC-G)en_US
dc.titleBioavailability of Tc-99m-paclitaxel-glucuronide (Tc-99m-PAC-G)en_US
dc.typeArticleen_US

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