The effect of radiolabeled antibiotics on biofilm and microorganism within biofilm

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dc.contributor.authorAvcibasi, Ugur
dc.contributor.authorDemiroglu, Hasan
dc.contributor.authorSakarya, Serhan
dc.contributor.authorUnak, Perihan
dc.contributor.authorTekin, Volkan
dc.contributor.authorAtes, Buket
dc.date.accessioned2019-10-27T10:41:57Z
dc.date.available2019-10-27T10:41:57Z
dc.date.issued2018
dc.departmentEge Üniversitesien_US
dc.description.abstractThe aim of this study was to investigate the I-131 and I-127 labeled linezolid and moxifloxacin effects of minimum inhibitory concentration, and minimum bactericidal concentration on mature biofilm and microorganism within the biofilm. Linezolid and moxifloxacin were labeled with I-131 and I-127 and chromatography studies were carried out with thin layer radiochromatograpy and high-pressure liquid radiochromatography techniques. Specific activities of radiolabeled LZD and MXF was found to be 53.3 +/- 3.1 and 127.3 +/- 1.1 MBq/A mu mol for [I-131]LZD and 7.6 +/- 0.02 and 55.6 +/- 0.8 MBq/A mu mol for [I-131]MXF, respectively. The minimum inhibitory concentration and Time-Kill of Linezolid and moxifloxacin alone and their I-131 and I-127 labeled forms were tested with a standard strain of meticillin-susceptible StaphylocA +/- ccus aureus. MIC values of LNZ and MXF were 2.96 nmol/mL (1 A mu g/ml) and 0.141 nmol/mL (0.062 A mu g/ml). Time Kills of MXF and LZD were found to be 0.06 and 1 mu g, respectively. Antibiotics labeled with beta-emitting radioactive molecule may be a new theranostics strategy for biofilm infections.en_US
dc.identifier.doi10.1007/s10967-018-5750-3
dc.identifier.endpage287en_US
dc.identifier.issn0236-5731
dc.identifier.issn1588-2780
dc.identifier.issn0236-5731en_US
dc.identifier.issn1588-2780en_US
dc.identifier.issue1en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage275en_US
dc.identifier.urihttps://doi.org/10.1007/s10967-018-5750-3
dc.identifier.urihttps://hdl.handle.net/11454/30561
dc.identifier.volume316en_US
dc.identifier.wosWOS:000427642400027en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofJournal of Radioanalytical and Nuclear Chemistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBiofilmen_US
dc.subjectLinezoliden_US
dc.subjectMoxifloxacinen_US
dc.subjectI-131en_US
dc.subjectI-127en_US
dc.subjectS. Aureusen_US
dc.subjectI-131 labelingen_US
dc.titleThe effect of radiolabeled antibiotics on biofilm and microorganism within biofilmen_US
dc.typeArticleen_US

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