IFNG and IFNGR1 gene polymorphisms in children with nonresponse to the hepatitis B vaccine

Küçük Resim Yok

Tarih

2014

Dergi Başlığı

Dergi ISSN

Cilt Başlığı

Yayıncı

Future Medicine Ltd

Erişim Hakkı

info:eu-repo/semantics/closedAccess

Özet

Aim: We investigated the +874 T/A polymorphism in the first intron of the IFNG gene and intronic (CA)(n) polymorphic microsatellite marker of the IFNGR1 gene in child nonresponders to hepatitisB vaccination. Materials & methods: A total of 100 children who had anti-HBs antibody levels <10 mIU/ml after vaccination against hepatitisB were included as a nonresponder group and 100 children who had anti-HBs antibody levels >10mIU/ml after vaccination against hepatitisB were included as a responder group. Results: The frequency of the TT genotype of the IFNG (+874 T/A) gene polymorphism was higher in nonresponders (p = 0.003). The frequencies of alleles 170 and 182 for (CA)(n) alleles for the intronic (CA)(n) microsatellite of IFNGR1 were significantly higher in nonresponders (for each, p<0.05). Conclusion: The TT genotype of the IFNG (+874 T/A) gene, and alleles 170 and 182 for (CA)(n) alleles for the intronic (CA)(n) microsatellite of the IFNGR1 gene, may be associated with nonresponse to hepatitisB vaccination.

Açıklama

Anahtar Kelimeler

child, gene polymorphism, hepatitisB, IFN-, interferon gamma, vaccine

Kaynak

Future Virology

WoS Q Değeri

Q4

Scopus Q Değeri

Q4

Cilt

9

Sayı

2

Künye