A Pencil Graphite Electrode In Situ Modified by Monovalent Copper: a Promising Tool for the Determination of Methylxanthines

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dc.contributor.authorNavratil, Rudolf
dc.contributor.authorJelen, Frantisek
dc.contributor.authorKayran, Yasin Ugur
dc.contributor.authorTrnkova, Libuse
dc.date.accessioned2019-10-27T22:15:24Z
dc.date.available2019-10-27T22:15:24Z
dc.date.issued2014
dc.departmentEge Üniversitesien_US
dc.description.abstractA pencil graphite electrode (PeGE) exhibits a promising tool for the electrochemical analysis of xanthine (Xan) and its N-methyl derivatives (1-, 3-, 7- and 9-mXan). The changes in their level in blood, serum, urine, as products of purine catabolism, can indicate the development of some diseases. Sensitivity-enhanced voltammetric detection of mXans was achieved by forming of complex with Cu(I) and application of elimination procedure. The Cu(I)-mXan complex was identified by means of titration of electrochemically produced cuprous ions by mXan. Our approach enables separation of overlapped mXan oxidation signals. Based on the obtained results, we found that the effect of methyl group position on the xanthine skeleton was significant and it was also discussed.en_US
dc.description.sponsorshipMinistry of Education, Youth and Sports of the Czech RepublicMinistry of Education, Youth & Sports - Czech Republic [LH 13053 KONTAKT II, MUNI/A/0972/2013]; CEITEC - Central European Institute of Technology [CZ. 1.05/1.1.00/02.0068]; NanoBioMetal-Net [CZ.1.07/2.4.00/31.0023]en_US
dc.description.sponsorshipThis research was supported by the following projects: LH 13053 KONTAKT II, MUNI/A/0972/2013 of the Ministry of Education, Youth and Sports of the Czech Republic, the CEITEC - Central European Institute of Technology Project CZ. 1.05/1.1.00/02.0068 and NanoBioMetal-Net CZ.1.07/2.4.00/31.0023.en_US
dc.identifier.doi10.1002/elan.201400017
dc.identifier.endpage961en_US
dc.identifier.issn1040-0397
dc.identifier.issn1521-4109
dc.identifier.issn1040-0397en_US
dc.identifier.issn1521-4109en_US
dc.identifier.issue5en_US
dc.identifier.startpage952en_US
dc.identifier.urihttps://doi.org/10.1002/elan.201400017
dc.identifier.urihttps://hdl.handle.net/11454/50167
dc.identifier.volume26en_US
dc.identifier.wosWOS:000335997600009en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.language.isoenen_US
dc.publisherWiley-V C H Verlag Gmbhen_US
dc.relation.ispartofElectroanalysisen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectMethylxanthinesen_US
dc.subjectPencil graphite electrodeen_US
dc.subjectElimination voltammetryen_US
dc.subjectCopper-purine complexesen_US
dc.titleA Pencil Graphite Electrode In Situ Modified by Monovalent Copper: a Promising Tool for the Determination of Methylxanthinesen_US
dc.typeArticleen_US

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