A case of acute lymphoblastic leukemia with additional chromosomes X and 5 associated with a Philadelphia chromosome in the bone marrow [Kemik ilig¨inde ekstra kromozom 5 ve x'e ilave philadelphia kromozomu içeren akut lenfoblastik lösemi olgusu]

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dc.contributor.authorDurmaz B.
dc.contributor.authorDurmaz A.A.
dc.contributor.authorKaraca E.
dc.contributor.authorSaydam, G..
dc.contributor.authorC¨og¨ulu O.
dc.contributor.authorÖzkınay F.
dc.date.accessioned2019-10-27T08:34:20Z
dc.date.available2019-10-27T08:34:20Z
dc.date.issued2010
dc.departmentEge Üniversitesien_US
dc.description.abstractWe report herein a very rare case of acute lymphoblastic leukemia having a chromosomal constitution of 48,XY,+X,+5,t(9;22)(q34;q11) in the bone marrow. A patient with additional chromosomes X and 5 with a Philadelphia chromosome has not been reported previously. However, no abnormal karyotype was obtained from the lymphocytes in our patient, and he did not have the characteristics of Klinefelter syndrome. He achieved a complete remission with IDA-FLAG and dasatinib therapy. The mechanism of trisomy 5 or any other chromosomal aneuploidy in the pathogenesis of leukemogenesis remains unclear. Further studies involving the genes affected by this karyotype and their products may lead to strategies to further increase the understanding of drug-resistant acute lymphoblastic leukemia and may represent the next frontier in the targeted therapy of those patients.en_US
dc.identifier.doi10.5152/tjh.2010.53
dc.identifier.endpage302en_US
dc.identifier.issn1300-7777
dc.identifier.issn1300-7777en_US
dc.identifier.issue4en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage299en_US
dc.identifier.urihttps://doi.org/10.5152/tjh.2010.53
dc.identifier.urihttps://hdl.handle.net/11454/27020
dc.identifier.volume27en_US
dc.indekslendigikaynakScopusen_US
dc.language.isotren_US
dc.relation.ispartofTurkish Journal of Hematologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectALLen_US
dc.subjectChromosome 5en_US
dc.subjectPhiladelphia chromosomeen_US
dc.subjectX chromosomeen_US
dc.titleA case of acute lymphoblastic leukemia with additional chromosomes X and 5 associated with a Philadelphia chromosome in the bone marrow [Kemik ilig¨inde ekstra kromozom 5 ve x'e ilave philadelphia kromozomu içeren akut lenfoblastik lösemi olgusu]en_US
dc.typeArticleen_US

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