Amino acid neurotransmitter levels in the cerebral cortex of mice receiving imipenem/cilastatin - Lack of excitotoxicity in the central nervous system

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dc.contributor.authorAkisu M.
dc.contributor.authorKultursay N.
dc.contributor.authorCoker C.
dc.contributor.authorAkisu C.
dc.contributor.authorBaka M.
dc.date.accessioned2019-10-27T00:32:05Z
dc.date.available2019-10-27T00:32:05Z
dc.date.issued1998
dc.departmentEge Üniversitesien_US
dc.description.abstractImipenem, a very potent carbapenem derivative beta-lactam antibiotic, has recently found a major place in the treatment of antibiotic-resistant nosocomial infections. However, a convulsive side effect is seen in 0.2-3 percent of patients. Although it is suggested that this effect is due to the inhibition of gamma-aminobutyric acid (GABA) mediated inhibitory transmission, no study has been reported so far showing its effect on the cerebral cortex free inhibitory and excitatory amino acid levels. Twenty-one male TO albino mice were divided into three equal groups and given therapeutic (40 mg/kg/day) or excessive (500 mg/kg/day) doses of imipenem/cilastatine (I/C) or saline solution intraperitoneally for 7 days. All animals in the excessive dose group showed seizure-like activity with ataxia and loss of gait. However, no differences in aspartate, glumatate, glycine or GABA levels were seen o gas chromatographic evaluation of the cerebral cortexes of all three groups of animals, which were dispatched on the 7th day. Therefore it is suggested that imipenem exerts its convulsive effect without causing any change in neurotransmitter levels of barin, possibly by effecting the neuronal receptors directly.en_US
dc.identifier.endpage498en_US
dc.identifier.issn1300-0144
dc.identifier.issn1300-0144en_US
dc.identifier.issue5en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage495en_US
dc.identifier.urihttps://hdl.handle.net/11454/23664
dc.identifier.volume28en_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.relation.ispartofTurkish Journal of Medical Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAmino aciden_US
dc.subjectImipenemen_US
dc.subjectMiceen_US
dc.subjectNeurotoxicityen_US
dc.titleAmino acid neurotransmitter levels in the cerebral cortex of mice receiving imipenem/cilastatin - Lack of excitotoxicity in the central nervous systemen_US
dc.typeArticleen_US

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