The synthesis and targeting of PPP-type copolymers to breast cancer cells: Multifunctional platforms for imaging and diagnosis

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dc.contributor.authorColak, Demet Goen
dc.contributor.authorCianga, Ioan
dc.contributor.authorDemirkol, Dilek Odaci
dc.contributor.authorKozgus, Ozge
dc.contributor.authorMedine, E. Ilker
dc.contributor.authorSakarya, Serhan
dc.contributor.authorUnak, Perihan
dc.contributor.authorTimur, Suna
dc.contributor.authorYagci, Yusuf
dc.date.accessioned2019-10-27T21:34:51Z
dc.date.available2019-10-27T21:34:51Z
dc.date.issued2012
dc.departmentEge Üniversitesien_US
dc.description.abstractHerein, we demonstrate the synthesis and application of water-soluble, biomolecule conjugated PPP copolymers bearing poly(ethylene glycol) (PEG) side chains as fluorescent probes for the in vitro imaging of cancer cells. The targeting of fluorescent polymers to breast cancer cells allows effective visualization and discrimination of MCF7 cells from human mammary epithelial cells. Furthermore, these materials are also suitable for efficient radiolabeling via I-125 which enables dual-modality holding the possibility of both radioactive and fluorescence imaging in cancer diagnosis applications.en_US
dc.description.sponsorshipTUBITAKTurkiye Bilimsel ve Teknolojik Arastirma Kurumu (TUBITAK) [109T573]; EBILTEM (Ege University, Research and Application Center of Science and Technology)Ege University [2010BIL004]; Istanbul Technical UniversityIstanbul Technical Universityen_US
dc.description.sponsorshipThis work was supported by TUBITAK (Project no 109T573), EBILTEM (Ege University, Research and Application Center of Science and Technology, Project no: 2010BIL004) and Istanbul Technical University Research Funds. One of the authors (I.C) thanks to TUBITAK for the financial support by means of "Visiting Scientist Fellowship Programme''. Authors also thank to METIS Biotechnology for the technical support and M. Aksoy for his valuable help during the in vivo imaging studies. Additionally, we appreciate R. Bongartz (Gottfried Wilhelm Leibniz University of Hannover, Institute for Technical Chemistry) for her valuable support during cytotoxicity experiments.en_US
dc.identifier.doi10.1039/c2jm30692a
dc.identifier.endpage9300en_US
dc.identifier.issn0959-9428
dc.identifier.issn1364-5501
dc.identifier.issn0959-9428en_US
dc.identifier.issn1364-5501en_US
dc.identifier.issue18en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage9293en_US
dc.identifier.urihttps://doi.org/10.1039/c2jm30692a
dc.identifier.urihttps://hdl.handle.net/11454/45712
dc.identifier.volume22en_US
dc.identifier.wosWOS:000302634800077en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherRoyal Soc Chemistryen_US
dc.relation.ispartofJournal of Materials Chemistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.titleThe synthesis and targeting of PPP-type copolymers to breast cancer cells: Multifunctional platforms for imaging and diagnosisen_US
dc.typeArticleen_US

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