Comparative biological evaluation and identification of multifunctional endogenous and exogenous bioactive peptides in different matured Izmir Tulum cheeses

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dc.authorid0000-0001-6479-7336
dc.authorid0000-0002-7244-3949
dc.authorid0000-0001-5611-5235
dc.authorid0000-0001-8216-7004
dc.authorid0000-0002-1532-4687
dc.authorid0000-0002-4274-2729
dc.authorid0000-0002-5811-9851
dc.contributor.authorAkan, Ecem
dc.contributor.authorTok, Kerem
dc.contributor.authorKocazorbaz, Ebru Kocadag
dc.contributor.authorZihnioglu, Figen
dc.contributor.authorYerlikaya, Oktay
dc.contributor.authorHayaloglu, Ali Adnan
dc.contributor.authorKinik, Ozer
dc.date.accessioned2025-03-18T07:20:59Z
dc.date.available2025-03-18T07:20:59Z
dc.date.issued2024
dc.departmentEge Üniversitesi, Ziraat Fakültesi, Süt Teknolojisi Bölümü
dc.description.abstractBioactive peptides redefine health and disease by triggering unique biological functions in the body. The aim of this study was to evaluate and identify the endogenous and exogenous peptides (in vitro gastrointestinal digestion) of 360-day ripened Izmir Tulum cheese manufactured using cow, sheep, and goat milk. Peptide extracts from Izmir Tulum cheeses were found to have DPP-IV inhibitory, deglycation, antioxidant, metal chelating, and ACE-inhibitory activity. After the activity guided purification of peptide extracts were performed by HPLC, 8 peptide fractions were selected according to their biological activity, and the peptide sequence of each peptide were identified by mass spectrometry. It was observed that the use of different types of milk in the manufacture of Izmir Tulum cheese affects peptide diversity, that endogenous and exogenous peptides had a wide range of potential biological activities, and that new bioactive peptides were obtained from Izmir Tulum cheese. The potential peptide sequences obtained from the identified fractions ETFHPLKHQ, EVVPGPFPQ, and TLGLHTPK are the first peptide sequences that do not overlap with sequences published in the literature. In conclusion, these endogenous and exogenous peptides of Izmir Tulum cheeses have significant biological activities associated with type 2 diabetes, deglycation, antioxidants, and metal chelating agents to support the immune system, and ACEinhibitory effects to treat hypertension. These new peptides could open a new avenue for the noval peptide-based drug and contribute to therapeutic applications.
dc.identifier.citationAkan, E., Tok, K., Kocazorbaz, E. K., Zihnioglu, F., Yerlikaya, O., Hayaloglu, A. A., & Kinik, O. (2025). Comparative biological evaluation and identification of multifunctional endogenous and exogenous bioactive peptides in different matured izmir tulum cheeses. International Dairy Journal, 161, 106141.
dc.identifier.doi10.1016/j.idairyj.2024.106141
dc.identifier.endpage7
dc.identifier.issn0958-6946
dc.identifier.issueNov
dc.identifier.scopus2-s2.0-85209363791
dc.identifier.scopusqualityQ2
dc.identifier.startpage1
dc.identifier.urihttps://doi.org/10.1016/j.idairyj.2024.106141
dc.identifier.urihttps://hdl.handle.net/11454/116778
dc.identifier.volume161
dc.identifier.wosWOS:001363972400001
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.institutionauthorTok, Kerem
dc.institutionauthorKocazorbaz, Ebru Kocadag
dc.institutionauthorZihnioglu, Figen
dc.institutionauthorYerlikaya, Oktay
dc.institutionauthorKinik, Ozer
dc.institutionauthorid0000-0002-7244-3949
dc.institutionauthorid0000-0001-5611-5235
dc.institutionauthorid0000-0001-8216-7004
dc.institutionauthorid0000-0002-1532-4687
dc.institutionauthorid0000-0002-5811-9851
dc.language.isoen
dc.publisherElsevier Sci Ltd
dc.relation.ispartofInternational Dairy Journal
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectAntidiabetic activity
dc.subjectAntihypertensive activity
dc.subjectDairy products
dc.subjectDeglycation
dc.subjectIn vitro digestion
dc.subjectIzmir Tulum cheese
dc.titleComparative biological evaluation and identification of multifunctional endogenous and exogenous bioactive peptides in different matured Izmir Tulum cheeses
dc.typeArticle

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