Effects of valsartan and enalapril on regression of left ventricular hypertrophy in patients with mild to moderate hypertension: A randomized, double-blind study

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dc.contributor.authorNalbantgil, S
dc.contributor.authorYilmaz, K
dc.contributor.authorGurun, C
dc.contributor.authorOzerkan, F
dc.contributor.authorNalbantgil, I
dc.contributor.authorOnder, R
dc.date.accessioned2019-10-27T18:22:53Z
dc.date.available2019-10-27T18:22:53Z
dc.date.issued2000
dc.departmentEge Üniversitesien_US
dc.description.abstractObjective: This study was undertaken to compare the effects of valsartan with those of enalapril on regression of left ventricular hypertrophy in patients with mild to moderate hypertension. Background: The effect of angiotensin II receptor antagonists on regression of left ventricular hypertrophy in patients with hypertension has been established in several studies. The effects of these agents have also been compared with those of other antihypertensive drugs such as diuretics or beta-receptor blocking agents. However, no study has compared angiotensin II receptor antagonists with angiotensin-converting-enzyme (ACE) inhibitors. The effect of ACE inhibitors on regression of left ventricular hypertrophy is superior to that of other antihypertensive drugs. Methods: Forty patients with mild to moderate hypertension and left ventricular hypertrophy were included in this randomized, double-blind study. Patients were divided into 2 groups. No between-group differences were noted with regard to age, systolic and diastolic blood pressures, duration of hypertension, and left ventricular mass index, which was measured by M-mode echocardiography. Twenty patients received enalapril 20 mg/d, and 20 patients received valsartan 80 mg/d. Echocardiographic measurements were repeated at 3 and 6 months, and blood pressure was measured every 15 days. Results: Systolic and diastolic blood pressures decreased significantly at 3 and 6 months in both groups (P < 0.001), as did left; ventricular mass index (P < 0.02 and P < 0.01, respectively). Cough and fatigue occurred in 3 (15%) and 2 (10%) patients in the enalapril group. No adverse effects were reported in the valsartan group. Conclusions.. In patients with left ventricular hypertrophy caused by hypertension, valsartan is as effective as enalapril in reducing left ventricular hypertrophy.en_US
dc.identifier.doi10.1016/S0011-393X(00)80002-8
dc.identifier.endpage338en_US
dc.identifier.issn0011-393X
dc.identifier.issn0011-393Xen_US
dc.identifier.issue6en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage331en_US
dc.identifier.urihttps://doi.org/10.1016/S0011-393X(00)80002-8
dc.identifier.urihttps://hdl.handle.net/11454/36054
dc.identifier.volume61en_US
dc.identifier.wosWOS:000087921800002en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherExcerpta Medica Incen_US
dc.relation.ispartofCurrent Therapeutic Research-Clinical and Experimentalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjecthypertensionen_US
dc.subjectleft ventricular hypertrophyen_US
dc.subjectenalaprilen_US
dc.subjectvalsartanen_US
dc.titleEffects of valsartan and enalapril on regression of left ventricular hypertrophy in patients with mild to moderate hypertension: A randomized, double-blind studyen_US
dc.typeArticleen_US

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