Antioxidant, cytotoxicity, antimicrobial, wound healing potentials and LC-MS/MS analysis of water extract of Rhus coriaria L. (sumak) leaves

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dc.authoridYavaşer Boncooğlu, Rukiye/0000-0003-2295-4617
dc.authoridBaşbülbül, Gamze/0000-0001-8151-6321
dc.authoriderdogan, omer/0000-0002-8327-7077
dc.contributor.authorAytar, Mehmet
dc.contributor.authorBoncooglu, Rukiye Yavaser
dc.contributor.authorErdogan, Omer
dc.contributor.authorBasbulbul, Gamze
dc.contributor.authorOzturk, Bintug
dc.date.accessioned2024-08-31T07:47:04Z
dc.date.available2024-08-31T07:47:04Z
dc.date.issued2024
dc.departmentEge Üniversitesien_US
dc.description.abstractThe object of this study was to investigate antioxidant, anticancer, antimicrobial and wound healing activities of aqueous extract of R. coriaria L. (sumak) leaves. Antioxidant activity was carried out using 1,1- diphenyl-2picrylhydrazyl (DPPH) and 2,2-azinobis(3 ethylbenzothiazoline-6-sulfonic acid) diammonium salt (ABTS) assays and the extract showed 97.0 +/- 0.74% and 95.7 +/- 1.40% radical scavenging activities, respectively. For anticancer activity, cytotoxicity was determined by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-2H-tetrazolium bromide (MTT) assay against MCF7 breast cancer and L929 mouse fibroblast cells, and the extract was able to inhibit proliferation of MCF7 breast cancer cells with IC 50 of 129.1 +/- 9.27 mu g/mL. Wound closure assay revealed that aqueous extract at 1 mu g/mL was able to close 79% of wound gap after 24 h with high migration rate. Antimicrobial activity depicted high inhibitory effects against C. albicans (17 mm), E. coli (16 mm), P. aeruginosa (21 mm), S. aureus (17 mm), K. pneumoniae (15 mm). Furthermore, LC-MS/MS results revealed that the leaves contain phenolic compounds and mainly rich in gallic acid (2.82 mg/kg) caffeic acid (6.84 mg/kg) and ascorbic acid (45.84 mg/kg) which may be strongly associated with the remarkable biological activities the extract.en_US
dc.identifier.doi10.1016/j.fbio.2024.104400
dc.identifier.issn2212-4292
dc.identifier.issn2212-4306
dc.identifier.scopus2-s2.0-85193962772en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://doi.org/10.1016/j.fbio.2024.104400
dc.identifier.urihttps://hdl.handle.net/11454/104303
dc.identifier.volume60en_US
dc.identifier.wosWOS:001247649100001en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.relation.ispartofFood Bioscienceen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmz20240831_Uen_US
dc.subjectAntioxidant Activityen_US
dc.subjectCytotoxicityen_US
dc.subjectAntimicrobial Activityen_US
dc.subjectRhus Coriaria L.en_US
dc.subjectSumaken_US
dc.subjectLc-Ms/Msen_US
dc.titleAntioxidant, cytotoxicity, antimicrobial, wound healing potentials and LC-MS/MS analysis of water extract of Rhus coriaria L. (sumak) leavesen_US
dc.typeArticleen_US

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