Differentiation of Neurons, Astrocytes, Oligodendrocytes and Microglia From Human Induced Pluripotent Stem Cells to Form Neural Tissue-On-Chip: A Neuroinflammation Model to Evaluate the Therapeutic Potential of Extracellular Vesicles Derived from Mesenchymal Stem Cells

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dc.authorscopusid57204924916
dc.authorscopusid58686453900
dc.authorscopusid57212369715
dc.authorscopusid57212299393
dc.authorscopusid22837401200
dc.contributor.authorSaglam-Metiner, P.
dc.contributor.authorDuran, E.
dc.contributor.authorSabour-Takanlou, L.
dc.contributor.authorBiray-Avci, C.
dc.contributor.authorYesil-Celiktas, O.
dc.date.accessioned2024-08-25T18:51:42Z
dc.date.available2024-08-25T18:51:42Z
dc.date.issued2023
dc.departmentEge Üniversitesien_US
dc.description.abstractAdvances in stem cell (SC) technology allow the generation of cellular models that recapitulate the histological, molecular and physiological properties of humanized in vitro three dimensional (3D) models, as well as production of cell-derived therapeutics such as extracellular vesicles (EVs). Improvements in organ-on-chip platforms and human induced pluripotent stem cells (hiPSCs) derived neural/glial cells provide unprecedented systems for studying 3D personalized neural tissue modeling with easy setup and fast output. Here, we highlight the key points in differentiation procedures for neurons, astrocytes, oligodendrocytes and microglia from single origin hiPSCs. Additionally, we present a well-defined humanized neural tissue-on-chip model composed of differentiated cells with the same genetic backgrounds, as well as the therapeutic potential of bone marrow mesenchymal stem cells (BMSCs)-derived extracellular vesicles to propose a novel treatment for neuroinflammation derived diseases. Around 100 nm CD9 + EVs promote a more anti-inflammatory and pro-remodeling of cell–cell interaction cytokine responses on tumor necrosis factor-? (TNF-?) induced neuroinflammation in neural tissue-on-chip model which is ideal for modeling authentic neural-glial patho-physiology. Graphical Abstract: [Figure not available: see fulltext.]. © 2023, The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.en_US
dc.description.sponsorshipTürkiye Bilimsel ve Teknolojik Araştırma Kurumu, TÜBİTAK: 119M578en_US
dc.identifier.doi10.1007/s12015-023-10645-8
dc.identifier.issn2629-3269
dc.identifier.scopus2-s2.0-85176127620en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://doi.org/10.1007/s12015-023-10645-8
dc.identifier.urihttps://hdl.handle.net/11454/102684
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofStem Cell Reviews and Reportsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmz20240825_Gen_US
dc.subjectDifferentiationen_US
dc.subjectExtracellular vesiclesen_US
dc.subjectInduced pluripotent stem cellsen_US
dc.subjectNeuroinflammationen_US
dc.subjectOrgan-on-a-chipen_US
dc.titleDifferentiation of Neurons, Astrocytes, Oligodendrocytes and Microglia From Human Induced Pluripotent Stem Cells to Form Neural Tissue-On-Chip: A Neuroinflammation Model to Evaluate the Therapeutic Potential of Extracellular Vesicles Derived from Mesenchymal Stem Cellsen_US
dc.typeArticleen_US

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