Histopathologic and immunophenotypic features of childhood and adult anaplastic large-cell lymphomas

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dc.contributor.authorHekimgil M.
dc.contributor.authorSoydan S.
dc.contributor.authorNart D.
dc.contributor.authorErtan Y.
dc.contributor.authorVeral A.
dc.contributor.authorÇagirgan S.
dc.contributor.authorÇetingül N.
dc.date.accessioned2019-10-27T00:24:56Z
dc.date.available2019-10-27T00:24:56Z
dc.date.issued2001
dc.departmentEge Üniversitesien_US
dc.description.abstractThe t(2;5) (p23; q35) translocation associated with CD30-positive anaplastic large-cell lymphoma (ALCL) creates a hybrid gene encoding the chimeric nucleolar protein nucleophosmin-anaplastic lymphoma kinase (NFM-ALK) protein, which can be demonstrated by immunostaining with ALK1 monoclonal antibody. In this study, 40 specimens of ALCL from 6 pediatric, 34 adult patients, were immunostained with monoclonal antibodies against CD30 (Ber-H2), EMA, CD45 (LCA), CD3, CD20 (L26), CD15, and ALK1 antigens, and results were correlated with histopathologic features. The mean age of the pediatric and adult patients was 10-years and 38-years, respectively. ALK1 was positive in 14 cases (35%) representing 83% of pediatric and 26% of adult patients, statistically significantly higher in the pediatric group (p= 0.01). Considering the better prognosis attributed to cases with t (2;5), it is interesting to note that the percentage of ALK1-positive cases is significantly higher in pediatric patients with coexpression of EMA, compared to adults.en_US
dc.identifier.endpage274en_US
dc.identifier.issn1300-7777
dc.identifier.issn1300-7777en_US
dc.identifier.issue4en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage265en_US
dc.identifier.urihttps://hdl.handle.net/11454/23162
dc.identifier.volume18en_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.relation.ispartofTurkish Journal of Haematologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectALK1en_US
dc.subjectAnaplastic large-cell lymphomaen_US
dc.subjectCD30en_US
dc.subjectEpithelial membrane antigenen_US
dc.titleHistopathologic and immunophenotypic features of childhood and adult anaplastic large-cell lymphomasen_US
dc.typeArticleen_US

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