Conducting spinal cord injury model with clip compression in rodents: Pearls and pitfalls

Basit Öğe Kaydı
dc.authorscopusid57208321979
dc.authorscopusid56496364100
dc.contributor.authorVahabi, A.
dc.contributor.authorÖztürk, A.M.
dc.date.accessioned2024-08-25T18:51:07Z
dc.date.available2024-08-25T18:51:07Z
dc.date.issued2023
dc.departmentEge Üniversitesien_US
dc.description.abstractResearch on spinal cord injuries is an important and living topic that raises many critical questions that need to be addressed. While numerous articles have compiled and compared various models of spinal cord injuries, there is limited comprehensive guide with clear instructions available for researchers who are unfamiliar with clip compression model. This model creates acute compression damage in spinal cord, which aims to mimic the nature of traumatic spinal cord damage in humans. Purpose of this article is to share our experience on clip compression model, with experience gained from more than 150 animals, and to provide guidance for researchers with lack of experience who wish to design studies with this model. We have defined several key variables, as well as the difficulties that may arise when applying this model. ? Proper preparation, good infrastructure and necessary tools and knowledge of anatomy related is essential to the success of this model. ? Good exposure with non-bleeding surgical site is key factor for surgical step. ? Postoperative care is particularly challenging, and researchers should consider extending their studies over a reasonable time period to ensure that appropriate care could be provided. © 2023en_US
dc.description.sponsorshipTGA-2021-23305; Ege Üniversitesien_US
dc.description.sponsorshipThe authors are grateful for the supervision of Prof. Dr. Taner Dağlı, who helped them become familiar with this model. The authors would also like to express their gratitude to Prof. Dr. Murat Olukman, the Head of Animal Research Laboratories at Ege University, for his kind assistance and mentorship. The authors wish to extend their appreciation to Bünyamin Kılıçlı, MD for his invaluable assistance with the animal experiments.en_US
dc.description.sponsorshipResearch projects that provided the authors with the experience discussed in this article were supported by the Ege University Scientific Research Committee (TGA-2021-23305).en_US
dc.identifier.doi10.1016/j.mex.2023.102231
dc.identifier.issn2215-0161
dc.identifier.scopus2-s2.0-85160596939en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://doi.org/10.1016/j.mex.2023.102231
dc.identifier.urihttps://hdl.handle.net/11454/102482
dc.identifier.volume10en_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherElsevier B.V.en_US
dc.relation.ispartofMethodsXen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmz20240825_Gen_US
dc.subjectAnimal experimenten_US
dc.subjectNerve injuryen_US
dc.subjectRaten_US
dc.subjectRodenten_US
dc.subjectSpine injuryen_US
dc.subjectaneurysm clippingen_US
dc.subjectanimal experimenten_US
dc.subjectanimal modelen_US
dc.subjectArticleen_US
dc.subjectcontrolled studyen_US
dc.subjectdisease modelen_US
dc.subjecthypovolemic shocken_US
dc.subjectlaminectomyen_US
dc.subjectmortality rateen_US
dc.subjectnonhumanen_US
dc.subjectoperative blood lossen_US
dc.subjectparaplegiaen_US
dc.subjectparaspinal muscleen_US
dc.subjectraten_US
dc.subjectspinal cord injuryen_US
dc.subjectspineen_US
dc.subjectsurgical mortalityen_US
dc.titleConducting spinal cord injury model with clip compression in rodents: Pearls and pitfallsen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

Scopus İndeksli Yayınlar Koleksiyonu