Progressive Multifocal Leukoencephalopathy in a Case Without Clear Evidence of Immunodeficiency

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dc.contributor.authorGuler, Ayse
dc.contributor.authorGokcay, Figen
dc.contributor.authorHaznedaroglu, Damla
dc.contributor.authorGokcay, Ahmet
dc.contributor.authorZeytinoglu, Aysin
dc.contributor.authorSagduyu, Ayse Kocaman
dc.contributor.authorSirin, Hadiye
dc.date.accessioned2019-10-27T21:33:52Z
dc.date.available2019-10-27T21:33:52Z
dc.date.issued2012
dc.departmentEge Üniversitesien_US
dc.description.abstractIntroduction: Progressive Multifocal Leukoencephalopathy(PML) is a rare demyelinating disease of the central nervous system due to reactivation of a latent infection with JC papovavirus. PML predominantly occurs in severely immunosupressed patients, mostly as a late complication of acquired immunodeficiency syndrome and lymphoproliferative disorders. Clinically it is manifested by motor and sensory deficits, ataxia, cognitive impairment and dementia, corresponding to central nervous system (CNS) lesions. It is difficult to distinguish PML clinically from immune-mediated diseases of the CNS, such as multiple sclerosis, neuropsychiatric sistemic lupus erythematosus and CNS vasculitis. Case Report: A 19-year-old woman presented with ataxia and slurred speech rapidly progressing to quadriparesis and confusion. The diagnosis of PML was made by detecting the JC virus in the cerebrospinal fluid by polymerase chain reaction. Discussion: PML predominantly occurs in severely immunosupressed patients. However, it must also be kept in mind in patients without an apparent immunodeficiency when the clinical and radiological features are typical.en_US
dc.identifier.endpage644en_US
dc.identifier.issn1302-1664
dc.identifier.issn1302-1664en_US
dc.identifier.issue3en_US
dc.identifier.startpage640en_US
dc.identifier.urihttps://hdl.handle.net/11454/45454
dc.identifier.volume29en_US
dc.identifier.wosWOS:000309218800026en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.language.isoenen_US
dc.publisherJournal Neurological Sciencesen_US
dc.relation.ispartofJournal of Neurological Sciences-Turkishen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectProgressive Multifocal Leukoencephalopathyen_US
dc.subjectImmunodeficiencyen_US
dc.subjectdemyelinating diseaseen_US
dc.subjectJC virusen_US
dc.titleProgressive Multifocal Leukoencephalopathy in a Case Without Clear Evidence of Immunodeficiencyen_US
dc.typeArticleen_US

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