Antihyperglycemic and antihyperlipidemic effects of ferula assa-foetida and ferula tenuissima extracts in diabetic rats

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dc.contributor.authorYusufoglu H.S.
dc.contributor.authorSoliman G.A.
dc.contributor.authorAbdel-Rahman R.F.
dc.contributor.authorAbdel-Kader M.S.
dc.contributor.authorGanaie M.A.
dc.contributor.authorBedir E.
dc.contributor.authorErel Ş.B.
dc.contributor.authorÖztürk B.
dc.date.accessioned2019-10-26T21:26:39Z
dc.date.available2019-10-26T21:26:39Z
dc.date.issued2015
dc.departmentEge Üniversitesien_US
dc.description.abstractThe present study was carried to explore the potential antihyperglycemic and antihyperlipidemic activity of Ferula assa-foetida L. and Ferula tenuissima Hub-Mor & Pesmen extracts in streptozotocin (STZ) induced diabetic rats. Furthermore, phytochemical screening, in vitro antioxidant activity and acute toxicity study of both plants were performed. Both extracts showed considerable antioxidant potential in vitro. In diabetic rats, F. assa-foetida (200 and 400 mg kg-1) and F. tenuissima (400 mg kgG1) showed significant elevation in plasma insulin level, total hemoglobin (Hb) and decrease in Fasting Blood Glucose (FBG) and glycosylated hemoglobin (HbA1c) levels. Significant elevations in the activities of superoxide dismutase (SOD), glutathione peroxidase (GPx), catalase (CAT) and level of reduced glutathione (GSH) in liver and pancreas homogenates were observed in diabetic animals following F. assa-foetida (200 and 400 mg kg-1) and F. tenuissima (400 mg kg-1) treatments. The antihyperlipidemic effect of F. assa-foetida extract was demonstrated by a significant reduction in plasma triglycerides (TG), Total Cholesterol (TC), Low Density Lipoprotein Cholesterol (LDL-C) and the increase of High Density Lipoprotein Cholesterol (HDL-C). Plasma activities of alanine transaminase (ALT), aspartate transaminase (AST) and alkaline phosphatase (ALP) and levels of Total Protein (TP) and bilirubin (BIL) in diabetic rats were recovered significantly after F. assa-foetida and F. tenuissima treatment in comparison with diabetic controls. The present data suggest that F. assa-foetida have both antihyperglycemic and antihyperlipidemic effects with enhancement of insulin-secreting activity. © 2015 Asian Network for Scientific Information.en_US
dc.identifier.doi10.3923/pjbs.2015.314.323
dc.identifier.endpage323en_US
dc.identifier.issn1028-8880
dc.identifier.issn1028-8880en_US
dc.identifier.issue7en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage314en_US
dc.identifier.urihttps://doi.org/10.3923/pjbs.2015.314.323
dc.identifier.urihttps://hdl.handle.net/11454/17361
dc.identifier.volume18en_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherAsian Network for Scientific Informationen_US
dc.relation.ispartofPakistan Journal of Biological Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAntihyperglycemicen_US
dc.subjectAntihyperlipidemicen_US
dc.subjectApiaceaeen_US
dc.subjectFerulaen_US
dc.subjectStreptozotocinen_US
dc.titleAntihyperglycemic and antihyperlipidemic effects of ferula assa-foetida and ferula tenuissima extracts in diabetic ratsen_US
dc.typeArticleen_US

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