Tc-99m-exorphin-glucuronide in tumor diagnosis: Preparation and biodistribution studies in rats

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dc.contributor.authorErtay, T.
dc.contributor.authorUnak, P.
dc.contributor.authorOzdogan, O.
dc.contributor.authorBiber, F. Z.
dc.contributor.authorZihnioglu, F.
dc.contributor.authorMedine, E. I.
dc.contributor.authorDurak, H.
dc.date.accessioned2019-10-27T19:17:59Z
dc.date.available2019-10-27T19:17:59Z
dc.date.issued2006
dc.departmentEge Üniversitesien_US
dc.description.abstractA glucuronide derivative of exorphin C called exorphin C glucuronide was obtained by enzymatic synthesis and labeled with Tc-99m using glucoheptonate (GH) as bifunctional chelating agent. Labeling efficiency was 99.7 +/- 0.03%. Biodistribution studies were performed on normal and mammary tumor bearing albino Wistar rats. In addition, scintigraphic imaging with Tc-99m-GH-exorphin C glucuronide (Tc-99m-GEG) was performed. The radiopeptide-glucuronide is rapidly cleared via the urinary system showing lower liver uptake. Results demonstrated that Tc-99m-GEG can be used as a vehicle to target tumors.en_US
dc.identifier.doi10.1007/s10967-006-0226-2
dc.identifier.endpage28en_US
dc.identifier.issn0236-5731
dc.identifier.issn0236-5731en_US
dc.identifier.issue1en_US
dc.identifier.startpage21en_US
dc.identifier.urihttps://doi.org/10.1007/s10967-006-0226-2
dc.identifier.urihttps://hdl.handle.net/11454/38519
dc.identifier.volume269en_US
dc.identifier.wosWOS:000239298600004en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofJournal of Radioanalytical and Nuclear Chemistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.titleTc-99m-exorphin-glucuronide in tumor diagnosis: Preparation and biodistribution studies in ratsen_US
dc.typeArticleen_US

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