Cytotoxicity and Anti-Angiogenic Potential of a Macro Alga, Ulva rigida C. Agardh (Green Alga) from Izmir Bay (Turkey)

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dc.contributor.authorGüler C.
dc.contributor.authorGüner A.
dc.contributor.authorYavaşoğlu N.Ü.K.
dc.date.accessioned2024-08-31T07:42:33Z
dc.date.available2024-08-31T07:42:33Z
dc.date.issued2023
dc.departmentEge Üniversitesien_US
dc.description.abstractAbstract: Marine based organisms and their bioactive compounds are very attractive in terms of biomedical area. Due to marine ecosystem have harsh environment conditions; marine algae synthesize various bioactive compounds to survive. Genus Ulva (green macro algae) or sea lettuce species are the most abundant representatives abound in coastal waters and have various bioactive compounds. Therefore, Ulva sp. is extensively researched in especially cancer treatment. In this study, the ethanol extract of Ulva rigida C. Agardh collected from Izmir Bay was investigated by MTT, LDH, TAC, TOS and HET-CAM assays to determine its anticancer potential. The extract of U. rigida showed significant cytotoxic effect on human cervix adenocarcinoma (HeLa) cells (IC50 value is 21 ± 4.84 mg/L). The extract had a moderate anti-angiogenic activity (Score value is 0.98 ± 0.3 at 50 ?M concentration). Our results showed that U. rigida has a good potential cervical cancer therapy agent. © Pleiades Publishing, Inc. 2023.en_US
dc.identifier.doi10.1134/S1062359022603299
dc.identifier.endpageS269en_US
dc.identifier.issn1062-3590
dc.identifier.issueSuppl 3en_US
dc.identifier.scopus2-s2.0-85182645270en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpageS261en_US
dc.identifier.urihttps://doi.org/10.1134/S1062359022603299
dc.identifier.urihttps://hdl.handle.net/11454/103934
dc.identifier.volume50en_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherPleiades Publishingen_US
dc.relation.ispartofBiology Bulletinen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmz20240831_Uen_US
dc.subjectanti-angiogenesisen_US
dc.subjectanticanceren_US
dc.subjectgreen algaeen_US
dc.subjectmacro algaeen_US
dc.subjectUlva rigidaen_US
dc.titleCytotoxicity and Anti-Angiogenic Potential of a Macro Alga, Ulva rigida C. Agardh (Green Alga) from Izmir Bay (Turkey)en_US
dc.typeArticleen_US

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