Cimicifuga racemosa (L.) Nutt.: Pharmacological Effects, Using Areas and Current Clinical Data

Cimicifuga racemosa (L.) Nutt., also known as “black cohosh”, is a perennial herbaceous plant that has been widely used, particularly for its effects on physiological and neuroendocrine processes. This review aims to present a comprehensive evaluation of the pharmacological properties, active constituents, and current clinical data related to C. racemosa extracts. Bioactive components such as triterpene glycosides, phenolic acids, and flavonoids found in the plant contribute to its anti-inflammatory, antioxidant, and neuroregulatory effects. Studies have reported its potential to alleviate symptoms such as vasomotor disturbances, mood alterations, and sleep disorders. Although promising, the exact mechanisms of action remain under investigation, and further well-designed randomized clinical studies are needed to clarify its therapeutic role and ensure long-term safety. © 2026, Society of Pharmaceutical Sciences of Ankara (FABAD). All rights reserved.